Transposons reanimated in mice - PubMed (original) (raw)
Review
. 2005 Aug 12;122(3):322-5.
doi: 10.1016/j.cell.2005.07.024.
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- PMID: 16096053
- DOI: 10.1016/j.cell.2005.07.024
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Review
Transposons reanimated in mice
Timothy H Bestor. Cell. 2005.
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Abstract
Transposons have proved valuable in the genetic modification of many organisms but not mammals. New work reported by Ding et al. (2005) in this issue of Cell and by Collier et al. (2005) and Dupuy et al. (2005) in a recent issue of Nature now reveals that insertional mutagenesis in mammalian cells is possible thanks to modified derivatives of the piggyBac and Sleeping Beauty DNA transposons. However, the slow rate of proliferation of DNA transposons suggests that derivatives of the L1 retrotransposon might be more powerful for mutagenesis of germline cells. In either case, the future of transposon-driven genetic analyses of mice and other mammals looks promising.
Comment on
- Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.
Dupuy AJ, Akagi K, Largaespada DA, Copeland NG, Jenkins NA. Dupuy AJ, et al. Nature. 2005 Jul 14;436(7048):221-6. doi: 10.1038/nature03691. Nature. 2005. PMID: 16015321 - Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse.
Collier LS, Carlson CM, Ravimohan S, Dupuy AJ, Largaespada DA. Collier LS, et al. Nature. 2005 Jul 14;436(7048):272-6. doi: 10.1038/nature03681. Nature. 2005. PMID: 16015333 - Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice.
Ding S, Wu X, Li G, Han M, Zhuang Y, Xu T. Ding S, et al. Cell. 2005 Aug 12;122(3):473-83. doi: 10.1016/j.cell.2005.07.013. Cell. 2005. PMID: 16096065
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