Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action - PubMed (original) (raw)
. 2005 Sep 30;335(3):937-42.
doi: 10.1016/j.bbrc.2005.07.164.
Yuichiro Yamada, Katsushi Tsukiyama, Kazumasa Miyawaki, Masaya Hosokawa, Kazuaki Nagashima, Kentaro Toyoda, Rei Naitoh, Wataru Mizunoya, Tohru Fushiki, Takashi Kadowaki, Yutaka Seino
Affiliations
- PMID: 16105663
- DOI: 10.1016/j.bbrc.2005.07.164
Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action
Heying Zhou et al. Biochem Biophys Res Commun. 2005.
Abstract
Gut hormone gastric inhibitory polypeptide (GIP) stimulates insulin secretion from pancreatic beta-cells upon ingestion of nutrients. Inhibition of GIP signaling prevents the onset of obesity and consequent insulin resistance induced by high-fat diet. In this study, we investigated the role of GIP in accumulation of triglycerides into adipocytes and in fat oxidation peripherally using insulin receptor substrate (IRS)-1-deficient mice and revealed that IRS-1(-/-)GIPR(-/-) mice exhibited both reduced adiposity and ameliorated insulin resistance. Furthermore, increased gene expression of CD36 and UCP2 in liver, and increased expression and enzyme activity of 3-hydroxyacyl-CoA dehydrogenase in skeletal muscle of IRS-1(-/-)GIPR(-/-) mice might contribute to the lower respiratory quotient and the higher fat oxidation in light phase. These results suggest that GIP plays a crucial role in switching from fat oxidation to fat accumulation under the diminished insulin action as a potential target for secondary prevention of insulin resistance.
Similar articles
- Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice.
Naitoh R, Miyawaki K, Harada N, Mizunoya W, Toyoda K, Fushiki T, Yamada Y, Seino Y, Inagaki N. Naitoh R, et al. Biochem Biophys Res Commun. 2008 Nov 7;376(1):21-5. doi: 10.1016/j.bbrc.2008.08.052. Epub 2008 Aug 22. Biochem Biophys Res Commun. 2008. PMID: 18723001 - Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes.
Yamada C, Yamada Y, Tsukiyama K, Yamada K, Yamane S, Harada N, Miyawaki K, Seino Y, Inagaki N. Yamada C, et al. Biochem Biophys Res Commun. 2007 Dec 7;364(1):175-80. doi: 10.1016/j.bbrc.2007.09.128. Epub 2007 Oct 9. Biochem Biophys Res Commun. 2007. PMID: 17937928 - Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance.
Zhao B, Wall RJ, Yang J. Zhao B, et al. Biochem Biophys Res Commun. 2005 Nov 11;337(1):248-55. doi: 10.1016/j.bbrc.2005.09.044. Biochem Biophys Res Commun. 2005. PMID: 16182246 - Role of the gut Peptide glucose-induced insulinomimetic Peptide in energy balance.
Pfeiffer AF, Rudovich N, Weickert MO, Isken F. Pfeiffer AF, et al. Results Probl Cell Differ. 2010;52:183-8. doi: 10.1007/978-3-642-14426-4_15. Results Probl Cell Differ. 2010. PMID: 20865381 Review. - GIP or not GIP? That is the question.
Kieffer TJ. Kieffer TJ. Trends Pharmacol Sci. 2003 Mar;24(3):110-2. doi: 10.1016/S0165-6147(03)00031-2. Trends Pharmacol Sci. 2003. PMID: 12628351 Review.
Cited by
- The interplay of glucose-dependent insulinotropic polypeptide in adipose tissue.
Kagdi S, Lyons SA, Beaudry JL. Kagdi S, et al. J Endocrinol. 2024 Apr 27;261(3):e230361. doi: 10.1530/JOE-23-0361. Print 2024 Jun 1. J Endocrinol. 2024. PMID: 38579777 Free PMC article. Review. - Protective Effect of GIP against Monosodium Glutamate-Induced Ferroptosis in Mouse Hippocampal HT-22 Cells through the MAPK Signaling Pathway.
Ko J, Jang S, Kwon W, Kim SY, Jang S, Kim E, Ji YR, Park S, Kim MO, Choi SK, Cho DH, Lee HS, Lim SG, Ryoo ZY. Ko J, et al. Antioxidants (Basel). 2022 Jan 19;11(2):189. doi: 10.3390/antiox11020189. Antioxidants (Basel). 2022. PMID: 35204073 Free PMC article. - Free fatty acids, glicentin and glucose-dependent insulinotropic polypeptide as potential major determinants of fasting substrate oxidation.
Hummel J, Fritsche L, Vosseler A, Dannecker C, Hoene M, Kantartzis K, Häring HU, Stefan N, Machann J, Birkenfeld AL, Weigert C, Wagner R, Peter A, Fritsche A, Heni M. Hummel J, et al. Sci Rep. 2021 Aug 17;11(1):16642. doi: 10.1038/s41598-021-95750-9. Sci Rep. 2021. PMID: 34404813 Free PMC article. - Acetate Does Not Affect Palmitate Oxidation and AMPK Phosphorylation in Human Primary Skeletal Muscle Cells.
González Hernández MA, Blaak EE, Hoebers NTH, Essers YPG, Canfora EE, Jocken JWE. González Hernández MA, et al. Front Endocrinol (Lausanne). 2021 Jun 17;12:659928. doi: 10.3389/fendo.2021.659928. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34220709 Free PMC article. - Enteroendocrine Hormone Secretion and Metabolic Control: Importance of the Region of the Gut Stimulation.
Xie C, Jones KL, Rayner CK, Wu T. Xie C, et al. Pharmaceutics. 2020 Aug 21;12(9):790. doi: 10.3390/pharmaceutics12090790. Pharmaceutics. 2020. PMID: 32825608 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases