Hepatitis C and liver transplantation - PubMed (original) (raw)

Review

. 2005 Aug 18;436(7053):973-8.

doi: 10.1038/nature04083.

Affiliations

• PMID: 16107838
• DOI: 10.1038/nature04083

Review

Hepatitis C and liver transplantation

Robert S Brown. Nature. 2005.

Abstract

Liver transplantation is a life-saving therapy to correct liver failure, portal hypertension and hepatocellular carcinoma arising from hepatitis C infection. But despite the successful use of living donors and improvements in immunosuppression and antiviral therapy, organ demand continues to outstrip supply and recurrent hepatitis C with accelerated progression to cirrhosis of the graft is a frequent cause of graft loss and the need for retransplantation. Appropriate selection of candidates and timing of transplantation, coupled with better pre- and post-transplant antiviral therapy, are needed to improve outcomes.

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