Genome streamlining in a cosmopolitan oceanic bacterium - PubMed (original) (raw)

. 2005 Aug 19;309(5738):1242-5.

doi: 10.1126/science.1114057.

H James Tripp, Scott Givan, Mircea Podar, Kevin L Vergin, Damon Baptista, Lisa Bibbs, Jonathan Eads, Toby H Richardson, Michiel Noordewier, Michael S Rappé, Jay M Short, James C Carrington, Eric J Mathur

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Genome streamlining in a cosmopolitan oceanic bacterium

Stephen J Giovannoni et al. Science. 2005.

Abstract

The SAR11 clade consists of very small, heterotrophic marine alpha-proteobacteria that are found throughout the oceans, where they account for about 25% of all microbial cells. Pelagibacter ubique, the first cultured member of this clade, has the smallest genome and encodes the smallest number of predicted open reading frames known for a free-living microorganism. In contrast to parasitic bacteria and archaea with small genomes, P. ubique has complete biosynthetic pathways for all 20 amino acids and all but a few cofactors. P. ubique has no pseudogenes, introns, transposons, extrachromosomal elements, or inteins; few paralogs; and the shortest intergenic spacers yet observed for any cell.

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