Wilms' tumour: connecting tumorigenesis and organ development in the kidney - PubMed (original) (raw)
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doi: 10.1038/nrc1696.
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- PMID: 16110318
- DOI: 10.1038/nrc1696
Review
Wilms' tumour: connecting tumorigenesis and organ development in the kidney
Miguel N Rivera et al. Nat Rev Cancer. 2005 Sep.
Erratum in
- Nat Rev Cancer. 2005 Oct;5(10):835
Abstract
Wilms' tumour, or nephroblastoma, is a common childhood tumour that is intimately linked to early kidney development and is often associated with persistent embryonic renal tissue and other kidney abnormalities. WT1, the first gene found to be inactivated in Wilms' tumour, encodes a transcription factor that functions as both a tumour suppressor and a critical regulator of renal organogenesis. Our understanding of the roles of WT1 in tumour formation and organogenesis have advanced in parallel, providing a striking example of the intersection between tumour biology, cellular differentiation and normal organogenesis.
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