Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1 - PubMed (original) (raw)
. 2005 Oct;23(10):1269-73.
doi: 10.1038/nbt1131. Epub 2005 Aug 21.
Affiliations
- PMID: 16116419
- DOI: 10.1038/nbt1131
Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1
Michael Kube et al. Nat Biotechnol. 2005 Oct.
Abstract
Dehalococcoides species are strictly anaerobic bacteria, which catabolize many of the most toxic and persistent chlorinated aromatics and aliphatics by reductive dechlorination and are used for in situ bioremediation of contaminated sites. Our sequencing of the complete 1,395,502 base pair genome of Dehalococcoides strain CBDB1 has revealed the presence of 32 reductive-dehalogenase-homologous (rdh) genes, possibly conferring on the bacteria an immense dehalogenating potential. Most rdh genes were associated with genes encoding transcription regulators such as two-component regulatory systems or transcription regulators of the MarR-type. Four new paralog groups of rdh-associated genes without known function were detected. Comparison with the recently sequenced genome of Dehalococcoides ethenogenes strain 195 reveals a high degree of gene context conservation (synteny) but exceptionally high plasticity in all regions containing rdh genes, suggesting that these regions are under intense evolutionary pressure.
Comment in
- Bacteria to the rescue.
Seshadri R, Heidelberg J. Seshadri R, et al. Nat Biotechnol. 2005 Oct;23(10):1236-7. doi: 10.1038/nbt1005-1236. Nat Biotechnol. 2005. PMID: 16211064 No abstract available.
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