Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract - PubMed (original) (raw)
Comparative Study
doi: 10.1038/nn1520. Epub 2005 Aug 14.
Affiliations
- PMID: 16116452
- DOI: 10.1038/nn1520
Comparative Study
Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract
Yaobo Liu et al. Nat Neurosci. 2005 Sep.
Erratum in
- Nat Neurosci. 2006 Jan;9(1):147. Song, Xuejun [corrected to Song, Xue-Jun]
Abstract
Guidance cues along the longitudinal axis of the CNS are poorly understood. Wnt proteins attract ascending somatosensory axons to project from the spinal cord to the brain. Here we show that Wnt proteins repel corticospinal tract (CST) axons in the opposite direction. Several Wnt genes were found to be expressed in the mouse spinal cord gray matter, cupping the dorsal funiculus, in an anterior-to-posterior decreasing gradient along the cervical and thoracic cord. Wnts repelled CST axons in collagen gel assays through a conserved high-affinity receptor, Ryk, which is expressed in CST axons. Neonatal spinal cord secretes diffusible repellent(s) in an anterior-posterior graded fashion, with anterior cord being stronger, and the repulsive activity was blocked by antibodies to Ryk (anti-Ryk). Intrathecal injection of anti-Ryk blocked the posterior growth of CST axons. Therefore, Wnt proteins may have a general role in anterior-posterior guidance of multiple classes of axons.
Comment in
- Wnts send axons up and down the spinal cord.
Dickson BJ. Dickson BJ. Nat Neurosci. 2005 Sep;8(9):1130-2. doi: 10.1038/nn0905-1130. Nat Neurosci. 2005. PMID: 16127443 No abstract available.
Similar articles
- Repulsive Wnt signaling inhibits axon regeneration after CNS injury.
Liu Y, Wang X, Lu CC, Kerman R, Steward O, Xu XM, Zou Y. Liu Y, et al. J Neurosci. 2008 Aug 13;28(33):8376-82. doi: 10.1523/JNEUROSCI.1939-08.2008. J Neurosci. 2008. PMID: 18701700 Free PMC article. - Wnt-Ryk signaling mediates axon growth inhibition and limits functional recovery after spinal cord injury.
Miyashita T, Koda M, Kitajo K, Yamazaki M, Takahashi K, Kikuchi A, Yamashita T. Miyashita T, et al. J Neurotrauma. 2009 Jul;26(7):955-64. doi: 10.1089/neu.2008.0776. J Neurotrauma. 2009. PMID: 19473059 - Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling.
Lyuksyutova AI, Lu CC, Milanesio N, King LA, Guo N, Wang Y, Nathans J, Tessier-Lavigne M, Zou Y. Lyuksyutova AI, et al. Science. 2003 Dec 12;302(5652):1984-8. doi: 10.1126/science.1089610. Science. 2003. PMID: 14671310 - The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration.
Clark CE, Liu Y, Cooper HM. Clark CE, et al. Sci China Life Sci. 2014 Apr;57(4):366-71. doi: 10.1007/s11427-014-4640-3. Epub 2014 Mar 18. Sci China Life Sci. 2014. PMID: 24643419 Review. - Ryk: another heretical Wnt receptor defies the canon.
Cheyette BN. Cheyette BN. Sci STKE. 2004 Dec 14;2004(263):pe54. doi: 10.1126/stke.2632004pe54. Sci STKE. 2004. PMID: 15598975 Review.
Cited by
- Molecular programs guiding arealization of descending cortical pathways.
Abe P, Lavalley A, Morassut I, Santinha AJ, Roig-Puiggros S, Javed A, Klingler E, Baumann N, Prados J, Platt RJ, Jabaudon D. Abe P, et al. Nature. 2024 Sep 11. doi: 10.1038/s41586-024-07895-y. Online ahead of print. Nature. 2024. PMID: 39261725 - Wnt5a Promotes Axon Elongation in Coordination with the Wnt-Planar Cell Polarity Pathway.
Ahmad S, Attisano L. Ahmad S, et al. Cells. 2024 Jul 28;13(15):1268. doi: 10.3390/cells13151268. Cells. 2024. PMID: 39120298 Free PMC article. - Neural regeneration in the human central nervous system-from understanding the underlying mechanisms to developing treatments. Where do we stand today?
Kvistad CE, Kråkenes T, Gavasso S, Bø L. Kvistad CE, et al. Front Neurol. 2024 May 9;15:1398089. doi: 10.3389/fneur.2024.1398089. eCollection 2024. Front Neurol. 2024. PMID: 38803647 Free PMC article. Review. - Axon Fasciculation, Mediated by Transmembrane Semaphorins, Is Critical for the Establishment of Segmental Specificity of Corticospinal Circuits.
Gu Z, Matsuura K, Letelier A, Basista M, Craig C, Imai F, Yoshida Y. Gu Z, et al. J Neurosci. 2023 Aug 9;43(32):5753-5768. doi: 10.1523/JNEUROSCI.0073-22.2023. Epub 2023 Jun 21. J Neurosci. 2023. PMID: 37344234 Free PMC article. - Incorporating Combinatorial Approaches to Encourage Targeted Neural Stem/Progenitor Cell Integration Following Transplantation in Spinal Cord Injury.
Pieczonka K, Fehlings MG. Pieczonka K, et al. Stem Cells Transl Med. 2023 Apr 17;12(4):207-214. doi: 10.1093/stcltm/szad008. Stem Cells Transl Med. 2023. PMID: 36892546 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases