Transforming growth factor-beta: a key mediator of fibrosis - PubMed (original) (raw)
Review
Transforming growth factor-beta: a key mediator of fibrosis
Alain Mauviel. Methods Mol Med. 2005.
Abstract
Transforming growth factor (TGF)-beta is a prototypic multifunctional cytokine whose broad modulatory mechanisms affect numerous biological functions both at the cell and organism levels. These include, but are not limited to, control of immune functions, embryogenesis, carcinogenesis, tissue responses to injury, cell proliferation, extracellular matrix (ECM) synthesis and degradation, and cell migration. The identification of Smad proteins, TGF-beta receptor kinase substrates that translocate into the cell nucleus to act as transcription factors, has increased our understanding of the molecular mechanisms underlying TGF-beta action. This introductory chapter will outline the current knowledge on how specific signals initiated by the TGF-beta receptors are brought to the nucleus to regulate gene expression, with a specific emphasis on how such signaling relates to connective tissue remodeling, repair, and fibrosis.
Similar articles
- TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing.
Schiller M, Javelaud D, Mauviel A. Schiller M, et al. J Dermatol Sci. 2004 Aug;35(2):83-92. doi: 10.1016/j.jdermsci.2003.12.006. J Dermatol Sci. 2004. PMID: 15265520 Review. - Transforming growth factor-beta signaling through the Smad proteins: role in systemic sclerosis.
Verrecchia F, Mauviel A, Farge D. Verrecchia F, et al. Autoimmun Rev. 2006 Oct;5(8):563-9. doi: 10.1016/j.autrev.2006.06.001. Epub 2006 Jul 5. Autoimmun Rev. 2006. PMID: 17027893 Review. - TGF-beta signalling from cell membrane to nucleus through SMAD proteins.
Heldin CH, Miyazono K, ten Dijke P. Heldin CH, et al. Nature. 1997 Dec 4;390(6659):465-71. doi: 10.1038/37284. Nature. 1997. PMID: 9393997 Review. - Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation.
Verrecchia F, Mauviel A. Verrecchia F, et al. J Invest Dermatol. 2002 Feb;118(2):211-5. doi: 10.1046/j.1523-1747.2002.01641.x. J Invest Dermatol. 2002. PMID: 11841535 Review. - [Transforming growth factor-betas: smad signaling and roles in physiopathology].
Javelaud D, Mauviel A. Javelaud D, et al. Pathol Biol (Paris). 2004 Feb;52(1):50-4. doi: 10.1016/j.patbio.2003.10.002. Pathol Biol (Paris). 2004. PMID: 14761714 Review. French.
Cited by
- Electrical Stimulation-Based Twitch Exercise Suppresses Progression of Immobilization-Induced Muscle Fibrosis via Downregulation of PGC-1?/VEGF Pathway.
Honda Y, Takahashi A, Tanaka N, Kajiwara Y, Sasaki R, Kataoka H, Sakamoto J, Okita M. Honda Y, et al. Physiol Res. 2024 Apr 30;73(2):285-294. doi: 10.33549/physiolres.935212. Physiol Res. 2024. PMID: 38710059 Free PMC article. - The Senescent Heart-"Age Doth Wither Its Infinite Variety".
Vijayakumar A, Wang M, Kailasam S. Vijayakumar A, et al. Int J Mol Sci. 2024 Mar 22;25(7):3581. doi: 10.3390/ijms25073581. Int J Mol Sci. 2024. PMID: 38612393 Free PMC article. Review. - Cardiac arrhythmogenesis: roles of ion channels and their functional modification.
Lei M, Salvage SC, Jackson AP, Huang CL. Lei M, et al. Front Physiol. 2024 Mar 4;15:1342761. doi: 10.3389/fphys.2024.1342761. eCollection 2024. Front Physiol. 2024. PMID: 38505707 Free PMC article. Review. - MicroRNAs regulating signaling pathways in cardiac fibrosis: potential role of the exercise training.
Improta-Caria AC, Rodrigues LF, Joaquim VHA, De Sousa RAL, Fernandes T, Oliveira EM. Improta-Caria AC, et al. Am J Physiol Heart Circ Physiol. 2024 Mar 1;326(3):H497-H510. doi: 10.1152/ajpheart.00410.2023. Epub 2023 Dec 8. Am J Physiol Heart Circ Physiol. 2024. PMID: 38063810 Review. - Effect of angiotensin converting enzyme inhibitors and angiotensin II receptor blockers on need for operative intervention for idiopathic adhesive capsulitis.
Bi AS, Papalia AG, Romeo PV, Schoof LH, Kwon YW, Rokito AS, Zuckerman JD, Virk MS. Bi AS, et al. JSES Int. 2023 Jul 3;7(5):793-798. doi: 10.1016/j.jseint.2023.06.008. eCollection 2023 Sep. JSES Int. 2023. PMID: 37719830 Free PMC article.