Involvement of the SCF complex in the control of Cdh1 degradation in S-phase - PubMed (original) (raw)

doi: 10.4161/cc.4.9.2048. Epub 2005 Sep 20.

Affiliations

• PMID: 16123585
• DOI: 10.4161/cc.4.9.2048

Involvement of the SCF complex in the control of Cdh1 degradation in S-phase

Ramla Benmaamar et al. Cell Cycle. 2005 Sep.

Abstract

The anaphase promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that acts as a key regulator in the progression through mitosis (when mostly in complex with Cdc20) and as a stabilizer of the G1 phase (when in complex with Cdh1). Cdh1 is an activator of APC/C, and it has previously been reported that it is capable of mediating its own degradation during Go and G1. Herein, we show that the SCF complex (Skp1/Cul1/F-box protein/Roc1) intervenes in the surveillance of Cdh1 cellular abundance in S-phase.

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