Modulation of neuronal protein trafficking and function by palmitoylation - PubMed (original) (raw)
Review
Modulation of neuronal protein trafficking and function by palmitoylation
Kun Huang et al. Curr Opin Neurobiol. 2005 Oct.
Abstract
Modification of proteins with the lipid palmitate regulates targeting to specific vesicular compartments and synaptic membranes. Mounting evidence indicates that this lipid modification modulates diverse aspects of neuronal development and synaptic transmission. In particular, palmitoylation regulates the function of proteins that control neuronal differentiation, axonal pathfinding and filopodia formation. In addition, trafficking of numerous proteins associated with synaptic vesicle release machinery requires protein palmitoylation. Remarkably, reversible palmitoylation of specific scaffolding proteins and signaling molecules dynamically regulates ion channel clustering and synaptic strength. The recent discovery of enzymes that palmitoylate specific subsets of synaptic proteins suggests that this process is tightly controlled in neurons.
Similar articles
- Protein palmitoylation in neuronal development and synaptic plasticity.
Fukata Y, Fukata M. Fukata Y, et al. Nat Rev Neurosci. 2010 Mar;11(3):161-75. doi: 10.1038/nrn2788. Nat Rev Neurosci. 2010. PMID: 20168314 Review. - Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.
Huang K, Yanai A, Kang R, Arstikaitis P, Singaraja RR, Metzler M, Mullard A, Haigh B, Gauthier-Campbell C, Gutekunst CA, Hayden MR, El-Husseini A. Huang K, et al. Neuron. 2004 Dec 16;44(6):977-86. doi: 10.1016/j.neuron.2004.11.027. Neuron. 2004. PMID: 15603740 - Greasing transmission: palmitoylation at the synapse.
Washbourne P. Washbourne P. Neuron. 2004 Dec 16;44(6):901-2. doi: 10.1016/j.neuron.2004.12.010. Neuron. 2004. PMID: 15603731 Review. - Identification of PSD-95 Depalmitoylating Enzymes.
Yokoi N, Fukata Y, Sekiya A, Murakami T, Kobayashi K, Fukata M. Yokoi N, et al. J Neurosci. 2016 Jun 15;36(24):6431-44. doi: 10.1523/JNEUROSCI.0419-16.2016. J Neurosci. 2016. PMID: 27307232 Free PMC article. - Palmitoylation cycles and regulation of protein function (Review).
Baekkeskov S, Kanaani J. Baekkeskov S, et al. Mol Membr Biol. 2009 Jan;26(1):42-54. doi: 10.1080/09687680802680108. Epub 2009 Jan 30. Mol Membr Biol. 2009. PMID: 19169934 Review.
Cited by
- A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death.
Baldwin AC, Green CD, Olson LK, Moxley MA, Corbett JA. Baldwin AC, et al. Am J Physiol Endocrinol Metab. 2012 Jun 1;302(11):E1390-8. doi: 10.1152/ajpendo.00519.2011. Epub 2012 Mar 20. Am J Physiol Endocrinol Metab. 2012. PMID: 22436701 Free PMC article. - The role of post-translational modifications of huntingtin in the pathogenesis of Huntington's disease.
Wang Y, Lin F, Qin ZH. Wang Y, et al. Neurosci Bull. 2010 Apr;26(2):153-62. doi: 10.1007/s12264-010-1118-6. Neurosci Bull. 2010. PMID: 20332821 Free PMC article. - PalmPred: an SVM based palmitoylation prediction method using sequence profile information.
Kumari B, Kumar R, Kumar M. Kumari B, et al. PLoS One. 2014 Feb 19;9(2):e89246. doi: 10.1371/journal.pone.0089246. eCollection 2014. PLoS One. 2014. PMID: 24586628 Free PMC article. - Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis.
Ponimaskin E, Dityateva G, Ruonala MO, Fukata M, Fukata Y, Kobe F, Wouters FS, Delling M, Bredt DS, Schachner M, Dityatev A. Ponimaskin E, et al. J Neurosci. 2008 Sep 3;28(36):8897-907. doi: 10.1523/JNEUROSCI.2171-08.2008. J Neurosci. 2008. PMID: 18768683 Free PMC article. - Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver.
Shen LF, Chen YJ, Liu KM, Haddad ANS, Song IW, Roan HY, Chen LY, Yen JJY, Chen YJ, Wu JY, Chen YT. Shen LF, et al. Sci Rep. 2017 May 19;7(1):2182. doi: 10.1038/s41598-017-02159-4. Sci Rep. 2017. PMID: 28526873 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources