A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons - PubMed (original) (raw)
A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons
Ivo Lieberam et al. Neuron. 2005.
Free article
Abstract
Motor neurons, alone among neurons in the vertebrate CNS, extend axons out of the neural tube to innervate peripheral targets. Two classes of motor neurons, termed vMNs and dMNs, extend axons out of the neural tube via ventral and dorsal exit points, respectively, in accord with their homeodomain transcription factor repertoire. Downstream of these transcriptional codes, the cell surface receptors that shape initial motor axon trajectories have not been identified. We show here that the chemokine receptor Cxcr4 is expressed on the axons of vMNs as they follow their ventral trajectory, whereas its ligand, Cxcl12, is expressed by mesenchymal cells surrounding the ventral neural tube. Genetic studies reveal that Cxcl12-Cxcr4 signaling directs the ventral trajectory of spinal vMNs. In its absence, these neurons adopt a dMN-like trajectory, despite preservation of their vMN transcriptional identity. Thus, the status of Cxcr4 signaling helps to determine the initial axonal trajectory of mammalian motor neurons.
Comment in
- Chemokinetics.
Miller RJ, Tran PB. Miller RJ, et al. Neuron. 2005 Sep 1;47(5):621-3. doi: 10.1016/j.neuron.2005.08.012. Neuron. 2005. PMID: 16129389 Free PMC article.
Similar articles
- Chemokine receptors are expressed widely by embryonic and adult neural progenitor cells.
Tran PB, Ren D, Veldhouse TJ, Miller RJ. Tran PB, et al. J Neurosci Res. 2004 Apr 1;76(1):20-34. doi: 10.1002/jnr.20001. J Neurosci Res. 2004. PMID: 15048927 - Functional SDF1 alpha/CXCR4 signaling in the developing spinal cord.
Luo Y, Cai J, Xue H, Miura T, Rao MS. Luo Y, et al. J Neurochem. 2005 Apr;93(2):452-62. doi: 10.1111/j.1471-4159.2005.03049.x. J Neurochem. 2005. PMID: 15816868 - Chemokinetics.
Miller RJ, Tran PB. Miller RJ, et al. Neuron. 2005 Sep 1;47(5):621-3. doi: 10.1016/j.neuron.2005.08.012. Neuron. 2005. PMID: 16129389 Free PMC article. - Chemokines in hematopoiesis.
Broxmeyer HE. Broxmeyer HE. Curr Opin Hematol. 2008 Jan;15(1):49-58. doi: 10.1097/MOH.0b013e3282f29012. Curr Opin Hematol. 2008. PMID: 18043246 Review.
Cited by
- Motor axon pathfinding.
Bonanomi D, Pfaff SL. Bonanomi D, et al. Cold Spring Harb Perspect Biol. 2010 Mar;2(3):a001735. doi: 10.1101/cshperspect.a001735. Cold Spring Harb Perspect Biol. 2010. PMID: 20300210 Free PMC article. Review. - CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4.
Nagasawa T. Nagasawa T. J Mol Med (Berl). 2014 May;92(5):433-9. doi: 10.1007/s00109-014-1123-8. Epub 2014 Apr 11. J Mol Med (Berl). 2014. PMID: 24722947 Review. - CXCR4 and CXCL12 signaling regulates the development of extrinsic innervation to the colorectum.
Halasy V, Szőcs E, Soós Á, Kovács T, Pecsenye-Fejszák N, Hotta R, Goldstein AM, Nagy N. Halasy V, et al. Development. 2023 Apr 15;150(8):dev201289. doi: 10.1242/dev.201289. Epub 2023 Apr 20. Development. 2023. PMID: 37039233 Free PMC article. - CXCL12α/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals.
Negro S, Lessi F, Duregotti E, Aretini P, La Ferla M, Franceschi S, Menicagli M, Bergamin E, Radice E, Thelen M, Megighian A, Pirazzini M, Mazzanti CM, Rigoni M, Montecucco C. Negro S, et al. EMBO Mol Med. 2017 Aug;9(8):1000-1010. doi: 10.15252/emmm.201607257. EMBO Mol Med. 2017. PMID: 28559442 Free PMC article. - Motor axon exit from the mammalian spinal cord is controlled by the homeodomain protein Nkx2.9 via Robo-Slit signaling.
Bravo-Ambrosio A, Mastick G, Kaprielian Z. Bravo-Ambrosio A, et al. Development. 2012 Apr;139(8):1435-46. doi: 10.1242/dev.072256. Epub 2012 Mar 7. Development. 2012. PMID: 22399681 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases