Phytochemistry: ibuprofen-like activity in extra-virgin olive oil - PubMed (original) (raw)

. 2005 Sep 1;437(7055):45-6.

doi: 10.1038/437045a.

Affiliations

• PMID: 16136122
• DOI: 10.1038/437045a

Phytochemistry: ibuprofen-like activity in extra-virgin olive oil

Gary K Beauchamp et al. Nature. 2005.

Abstract

Newly pressed extra-virgin olive oil contains oleocanthal--a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen. We show here that this similar perception seems to be an indicator of a shared pharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen. Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.

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