Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors - PubMed (original) (raw)

Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors

Hamed Jafar-Nejad et al. Dev Cell. 2005 Sep.

Free article

Abstract

Asymmetric division of sensory organ precursors (SOPs) in Drosophila generates different cell types of the mature sensory organ. In a genetic screen designed to identify novel players in this process, we have isolated a mutation in Drosophila sec15, which encodes a component of the exocyst, an evolutionarily conserved complex implicated in intracellular vesicle transport. sec15(-) sensory organs contain extra neurons at the expense of support cells, a phenotype consistent with loss of Notch signaling. A vesicular compartment containing Notch, Sanpodo, and endocytosed Delta accumulates in basal areas of mutant SOPs. Based on the dynamic traffic of Sec15, its colocalization with the recycling endosomal marker Rab11, and the aberrant distribution of Rab11 in sec15 clones, we propose that a defect in Delta recycling causes cell fate transformation in sec15(-) sensory lineages. Our data indicate that Sec15 mediates a specific vesicle trafficking event to ensure proper neuronal fate specification in Drosophila.

PubMed Disclaimer

Comment in

Recycling polarity.
Somers WG, Chia W. Somers WG, et al. Dev Cell. 2005 Sep;9(3):312-3. doi: 10.1016/j.devcel.2005.08.007. Dev Cell. 2005. PMID: 16139221 Review.

Cited by

Null mutation of exocyst complex component 3-like does not affect vascular development in mice.
Takashima S, Okamura E, Ichiyama Y, Nishi K, Shimizu A, Watanabe C, Muto M, Matsumoto S, Tsukiyama-Fujii S, Tsukiyama T, Ogita H, Nishi E, Ohji M, Sugiyama F, Takahashi S, Mizuno S, Mizutani KI, Ema M. Takashima S, et al. Exp Anim. 2024 Feb 14;73(1):93-100. doi: 10.1538/expanim.23-0105. Epub 2023 Sep 1. Exp Anim. 2024. PMID: 37661429 Free PMC article.
ArfGAP1 regulates the endosomal sorting of guidance receptors to promote directed collective cell migration in vivo.
Boutet A, Zeledon C, Emery G. Boutet A, et al. iScience. 2023 Jul 25;26(8):107467. doi: 10.1016/j.isci.2023.107467. eCollection 2023 Aug 18. iScience. 2023. PMID: 37599820 Free PMC article.
Essential Roles of Exocyst Complex Component 3-like 2 on Cardiovascular Development in Mice.
Watanabe C, Shibuya H, Ichiyama Y, Okamura E, Tsukiyama-Fujii S, Tsukiyama T, Matsumoto S, Matsushita J, Azami T, Kubota Y, Ohji M, Sugiyama F, Takahashi S, Mizuno S, Tamura M, Mizutani KI, Ema M. Watanabe C, et al. Life (Basel). 2022 Oct 28;12(11):1730. doi: 10.3390/life12111730. Life (Basel). 2022. PMID: 36362885 Free PMC article.
The exocyst complex is required for developmental and regenerative neurite growth in vivo.
Swope RD, Hertzler JI, Stone MC, Kothe GO, Rolls MM. Swope RD, et al. Dev Biol. 2022 Dec;492:1-13. doi: 10.1016/j.ydbio.2022.09.005. Epub 2022 Sep 24. Dev Biol. 2022. PMID: 36162553 Free PMC article.
Evolutionary plasticity in the requirement for force exerted by ligand endocytosis to activate C. elegans Notch proteins.
Langridge PD, Garcia Diaz A, Chan JY, Greenwald I, Struhl G. Langridge PD, et al. Curr Biol. 2022 May 23;32(10):2263-2271.e6. doi: 10.1016/j.cub.2022.03.025. Epub 2022 Mar 28. Curr Biol. 2022. PMID: 35349791 Free PMC article.

Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors - PubMed (original) (raw)