Vaccine-induced CD8+ central memory T cells in protection from simian AIDS - PubMed (original) (raw)
Vaccine-induced CD8+ central memory T cells in protection from simian AIDS
Monica Vaccari et al. J Immunol. 2005.
Abstract
Critical to the development of an effective HIV vaccine is the identification of adaptive immune responses that prevent infection or disease. In this study we demonstrate in a relevant nonhuman primate model of AIDS that the magnitude of vaccine-induced virus-specific CD8(+) central memory T cells (T(CM)), but not that of CD8(+) effector memory T cells, inversely correlates with the level of SIVmac251 replication, suggesting their pivotal role in the control of viral replication. We propose that effective preventive or therapeutic T cell vaccines for HIV-1 should induce long-term protective central memory T cells.
Similar articles
- Containment of simian immunodeficiency virus infection in vaccinated macaques: correlation with the magnitude of virus-specific pre- and postchallenge CD4+ and CD8+ T cell responses.
Hel Z, Nacsa J, Tryniszewska E, Tsai WP, Parks RW, Montefiori DC, Felber BK, Tartaglia J, Pavlakis GN, Franchini G. Hel Z, et al. J Immunol. 2002 Nov 1;169(9):4778-87. doi: 10.4049/jimmunol.169.9.4778. J Immunol. 2002. PMID: 12391187 - Sustained suppression of SHIV89.6P replication in macaques by vaccine-induced CD8+ memory T cells.
Yin J, Dai A, Kutzler MA, Shen A, Lecureux J, Lewis MG, Waldmann T, Weiner DB, Boyer JD. Yin J, et al. AIDS. 2008 Sep 12;22(14):1739-48. doi: 10.1097/QAD.0b013e32830efdae. AIDS. 2008. PMID: 18753858 - HIV vaccine development in the nonhuman primate model of AIDS.
Smith SM. Smith SM. J Biomed Sci. 2002 Mar-Apr;9(2):100-11. doi: 10.1007/BF02256020. J Biomed Sci. 2002. PMID: 11914576 Review. - Is a Human CD8 T-Cell Vaccine Possible, and if So, What Would It Take? CD8 T-Cell Vaccines: To B or Not to B?
Beura LK, Jameson SC, Masopust D. Beura LK, et al. Cold Spring Harb Perspect Biol. 2018 Sep 4;10(9):a028910. doi: 10.1101/cshperspect.a028910. Cold Spring Harb Perspect Biol. 2018. PMID: 29254982 Free PMC article. Review.
Cited by
- CD8+ T-cell memory in tumor immunology and immunotherapy.
Klebanoff CA, Gattinoni L, Restifo NP. Klebanoff CA, et al. Immunol Rev. 2006 Jun;211:214-24. doi: 10.1111/j.0105-2896.2006.00391.x. Immunol Rev. 2006. PMID: 16824130 Free PMC article. Review. - Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection.
Makedonas G, Betts MR. Makedonas G, et al. Springer Semin Immunopathol. 2006 Nov;28(3):209-19. doi: 10.1007/s00281-006-0025-4. Epub 2006 Aug 25. Springer Semin Immunopathol. 2006. PMID: 16932955 Review. No abstract available. - Comparison of human memory CD8 T cell responses to adenoviral early and late proteins in peripheral blood and lymphoid tissue.
Joshi A, Zhao B, Romanowski C, Rosen D, Flomenberg P. Joshi A, et al. PLoS One. 2011;6(5):e20068. doi: 10.1371/journal.pone.0020068. Epub 2011 May 27. PLoS One. 2011. PMID: 21637763 Free PMC article. - The CD8 T-cell road to immunotherapy of toxoplasmosis.
Bhadra R, Gigley JP, Khan IA. Bhadra R, et al. Immunotherapy. 2011 Jun;3(6):789-801. doi: 10.2217/imt.11.68. Immunotherapy. 2011. PMID: 21668315 Free PMC article. Review. - Choosing the right memory T cell for HIV.
Franchini G. Franchini G. Nat Med. 2009 Mar;15(3):244-6. doi: 10.1038/nm0309-244. Nat Med. 2009. PMID: 19265821 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials