Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression - PubMed (original) (raw)

Review

doi: 10.1038/nrc1694.

Affiliations

• PMID: 16148886
• DOI: 10.1038/nrc1694

Review

Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression

Thomas Brabletz et al. Nat Rev Cancer. 2005 Sep.

Abstract

The dissemination of tumour cells is the prerequisite of metastases and is correlated with a loss of epithelial differentiation and the acquisition of a migratory phenotype, a hallmark of malignant tumour progression. A stepwise, irreversible accumulation of genetic alterations is considered to be the responsible driving force. But strikingly, metastases of most carcinomas recapitulate the organization of their primary tumours. Although current models explain distinct and important aspects of carcinogenesis, each alone can not explain the sum of the cellular changes apparent in human cancer progression. We suggest an extended, integrated model that is consistent with all aspects of human tumour progression - the 'migrating cancer stem (MCS)-cell' concept.

PubMed Disclaimer

Similar articles

• Epithelial-mesenchymal and mesenchymal-epithelial transitions during cancer progression.
  Spaderna S, Schmalhofer O, Hlubek F, Jung A, Kirchner T, Brabletz T. Spaderna S, et al. Verh Dtsch Ges Pathol. 2007;91:21-8. Verh Dtsch Ges Pathol. 2007. PMID: 18314592
• Is repetitive wounding and bone marrow-derived stem cell mediated-repair an etiology of lung cancer development and dissemination?
  Haura EB. Haura EB. Med Hypotheses. 2006;67(4):951-6. doi: 10.1016/j.mehy.2005.12.050. Epub 2006 May 22. Med Hypotheses. 2006. PMID: 16714090
• Tumour-microenvironmental interactions: paths to progression and targets for treatment.
  Box C, Rogers SJ, Mendiola M, Eccles SA. Box C, et al. Semin Cancer Biol. 2010 Jun;20(3):128-38. doi: 10.1016/j.semcancer.2010.06.004. Epub 2010 Jul 3. Semin Cancer Biol. 2010. PMID: 20599506 Review.
• [Epithelial-mesenchymal transition in cancer progression].
  Gos M, Miłoszewska J, Przybyszewska M. Gos M, et al. Postepy Biochem. 2009;55(2):121-8. Postepy Biochem. 2009. PMID: 19824467 Review. Polish.
• Increased cell hydration promotes both tumor growth and metastasis: a biochemical mechanism consistent with genetic signatures.
  McIntyre GI. McIntyre GI. Med Hypotheses. 2007;69(5):1127-30. doi: 10.1016/j.mehy.2007.01.080. Epub 2007 Mar 30. Med Hypotheses. 2007. PMID: 17399912

Cited by

• EMT-Inducing Transcription Factors, Drivers of Melanoma Phenotype Switching, and Resistance to Treatment.
  Tang Y, Durand S, Dalle S, Caramel J. Tang Y, et al. Cancers (Basel). 2020 Aug 4;12(8):2154. doi: 10.3390/cancers12082154. Cancers (Basel). 2020. PMID: 32759677 Free PMC article. Review.
• Phenolic secoiridoids in extra virgin olive oil impede fibrogenic and oncogenic epithelial-to-mesenchymal transition: extra virgin olive oil as a source of novel antiaging phytochemicals.
  Vazquez-Martin A, Fernández-Arroyo S, Cufí S, Oliveras-Ferraros C, Lozano-Sánchez J, Vellón L, Micol V, Joven J, Segura-Carretero A, Menendez JA. Vazquez-Martin A, et al. Rejuvenation Res. 2012 Feb;15(1):3-21. doi: 10.1089/rej.2011.1203. Epub 2012 Jan 9. Rejuvenation Res. 2012. PMID: 22229524 Free PMC article.
• Altered Transcriptional Control Networks with Trans-Differentiation of Isogenic Mutant-KRas NSCLC Models.
  Haley JA, Haughney E, Ullman E, Bean J, Haley JD, Fink MY. Haley JA, et al. Front Oncol. 2014 Dec 8;4:344. doi: 10.3389/fonc.2014.00344. eCollection 2014. Front Oncol. 2014. PMID: 25538889 Free PMC article.
• Increased autophagic response in a population of metastatic breast cancer cells.
  Li YI, Libby EF, Lewis MJ, Liu J, Shacka JJ, Hurst DR. Li YI, et al. Oncol Lett. 2016 Jul;12(1):523-529. doi: 10.3892/ol.2016.4613. Epub 2016 May 24. Oncol Lett. 2016. PMID: 27347175 Free PMC article.
• Biological rationale for the design of polymeric anti-cancer nanomedicines.
  Zhou Y, Kopeček J. Zhou Y, et al. J Drug Target. 2013 Jan;21(1):1-26. doi: 10.3109/1061186X.2012.723213. Epub 2012 Sep 26. J Drug Target. 2013. PMID: 23009337 Free PMC article. Review.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information