Regional cortical thinning in preclinical Huntington disease and its relationship to cognition - PubMed (original) (raw)
Regional cortical thinning in preclinical Huntington disease and its relationship to cognition
H D Rosas et al. Neurology. 2005.
Abstract
The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.
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