Like cops on the beat: the active role of resting microglia - PubMed (original) (raw)
Review
Like cops on the beat: the active role of resting microglia
Gennadij Raivich. Trends Neurosci. 2005 Nov.
Abstract
Microglia form the first line of defence for the neural parenchyma. But do these cells pursue an active role in the normal brain, or do they become activated only after injury? Two papers published recently by Nimmerjahn et al. and Davalos et al. used in vivo two-photon laser-scanning microscopy reveal that the fine branches of 'resting' microglia are highly mobile, and provide extensive and continuous surveillance of their cellular environment. These moving branches show a rapid chemotactic response to tissue injury that depends on purine receptors and connexin hemichannels, and they appear to take cues from surrounding astrocytes both in the normal and the injured brain.
Similar articles
- Juxtavascular microglia migrate along brain microvessels following activation during early postnatal development.
Grossmann R, Stence N, Carr J, Fuller L, Waite M, Dailey ME. Grossmann R, et al. Glia. 2002 Mar 1;37(3):229-40. Glia. 2002. PMID: 11857681 - Immune function of microglia.
Aloisi F. Aloisi F. Glia. 2001 Nov;36(2):165-79. doi: 10.1002/glia.1106. Glia. 2001. PMID: 11596125 Review. - Neuroscience. Brain under surveillance: the microglia patrol.
Fetler L, Amigorena S. Fetler L, et al. Science. 2005 Jul 15;309(5733):392-3. doi: 10.1126/science.1114852. Science. 2005. PMID: 16020721 No abstract available. - Functions of microglia in the central nervous system--beyond the immune response.
Wake H, Moorhouse AJ, Nabekura J. Wake H, et al. Neuron Glia Biol. 2011 Feb;7(1):47-53. doi: 10.1017/S1740925X12000063. Epub 2012 May 22. Neuron Glia Biol. 2011. PMID: 22613055 Review. - Signaling Pathways Controlling Microglia Chemotaxis.
Fan Y, Xie L, Chung CY. Fan Y, et al. Mol Cells. 2017 Mar;40(3):163-168. doi: 10.14348/molcells.2017.0011. Epub 2017 Mar 17. Mol Cells. 2017. PMID: 28301917 Free PMC article. Review.
Cited by
- Microglia activation: one of the checkpoints in the CNS inflammation caused by Angiostrongylus cantonensis infection in rodent model.
Wei J, Wu F, He A, Zeng X, Ouyang LS, Liu MS, Zheng HQ, Lei WL, Wu ZD, Lv ZY. Wei J, et al. Parasitol Res. 2015 Sep;114(9):3247-54. doi: 10.1007/s00436-015-4541-9. Epub 2015 May 24. Parasitol Res. 2015. PMID: 26002828 - Three-dimensional morphometric analysis reveals time-dependent structural changes in microglia and astrocytes in the central amygdala and hypothalamic paraventricular nucleus of heart failure rats.
Althammer F, Ferreira-Neto HC, Rubaharan M, Roy RK, Patel AA, Murphy A, Cox DN, Stern JE. Althammer F, et al. J Neuroinflammation. 2020 Jul 23;17(1):221. doi: 10.1186/s12974-020-01892-4. J Neuroinflammation. 2020. PMID: 32703230 Free PMC article. - Microglia: key elements in neural development, plasticity, and pathology.
Eyo UB, Dailey ME. Eyo UB, et al. J Neuroimmune Pharmacol. 2013 Jun;8(3):494-509. doi: 10.1007/s11481-013-9434-z. Epub 2013 Jan 27. J Neuroimmune Pharmacol. 2013. PMID: 23354784 Free PMC article. Review. - Regulation of microglia by ionotropic glutamatergic and GABAergic neurotransmission.
Wong WT, Wang M, Li W. Wong WT, et al. Neuron Glia Biol. 2011 Feb;7(1):41-6. doi: 10.1017/S1740925X11000123. Epub 2011 Dec 14. Neuron Glia Biol. 2011. PMID: 22166726 Free PMC article. Review. - Potential Mechanisms and Clinical Effectiveness of Acupuncture in Depression.
Yang NN, Lin LL, Li YJ, Li HP, Cao Y, Tan CX, Hao XW, Ma SM, Wang L, Liu CZ. Yang NN, et al. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Curr Neuropharmacol. 2022. PMID: 35168522 Free PMC article. Review.