Closer to the source: notch and the nature of thymus-settling cells - PubMed (original) (raw)
Review
Closer to the source: notch and the nature of thymus-settling cells
Valerie P Zediak et al. Immunity. 2005 Sep.
Free article
Abstract
Questions regarding T cell development have recently received much attention, but the earliest intrathymic differentiation steps in adult mice have remained controversial. Three new papers together show that for at least some thymus-settling precursors, the loss of B lineage potential occurs in the thymus, and Notch acts on multipotent progenitors early after thymic entry.
Similar articles
- Bone marrow-derived hemopoietic precursors commit to the T cell lineage only after arrival in the thymic microenvironment.
Heinzel K, Benz C, Martins VC, Haidl ID, Bleul CC. Heinzel K, et al. J Immunol. 2007 Jan 15;178(2):858-68. doi: 10.4049/jimmunol.178.2.858. J Immunol. 2007. PMID: 17202347 - Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway.
Tydell CC, David-Fung ES, Moore JE, Rowen L, Taghon T, Rothenberg EV. Tydell CC, et al. J Immunol. 2007 Jul 1;179(1):421-38. doi: 10.4049/jimmunol.179.1.421. J Immunol. 2007. PMID: 17579063 - A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision.
Benz C, Bleul CC. Benz C, et al. J Exp Med. 2005 Jul 4;202(1):21-31. doi: 10.1084/jem.20050146. Epub 2005 Jun 27. J Exp Med. 2005. PMID: 15983065 Free PMC article. - T lineage progenitors: the earliest steps en route to T lymphocytes.
Wu L. Wu L. Curr Opin Immunol. 2006 Apr;18(2):121-6. doi: 10.1016/j.coi.2006.01.006. Epub 2006 Feb 3. Curr Opin Immunol. 2006. PMID: 16459068 Review. - Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from.
Bhandoola A, von Boehmer H, Petrie HT, Zúñiga-Pflücker JC. Bhandoola A, et al. Immunity. 2007 Jun;26(6):678-89. doi: 10.1016/j.immuni.2007.05.009. Immunity. 2007. PMID: 17582341 Review.
Cited by
- The development and function of thymic B cells.
Perera J, Huang H. Perera J, et al. Cell Mol Life Sci. 2015 Jul;72(14):2657-63. doi: 10.1007/s00018-015-1895-1. Epub 2015 Apr 3. Cell Mol Life Sci. 2015. PMID: 25837998 Free PMC article. Review. - Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection.
Perera J, Meng L, Meng F, Huang H. Perera J, et al. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17011-6. doi: 10.1073/pnas.1313001110. Epub 2013 Sep 30. Proc Natl Acad Sci U S A. 2013. PMID: 24082098 Free PMC article. - T-cell lineage determination.
Yang Q, Jeremiah Bell J, Bhandoola A. Yang Q, et al. Immunol Rev. 2010 Nov;238(1):12-22. doi: 10.1111/j.1600-065X.2010.00956.x. Immunol Rev. 2010. PMID: 20969581 Free PMC article. Review. - Notch ligand delta-like 4 regulates development and pathogenesis of allergic airway responses by modulating IL-2 production and Th2 immunity.
Jang S, Schaller M, Berlin AA, Lukacs NW. Jang S, et al. J Immunol. 2010 Nov 15;185(10):5835-44. doi: 10.4049/jimmunol.1000175. Epub 2010 Oct 13. J Immunol. 2010. PMID: 20944009 Free PMC article. - Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13.
Wu X, Yamamoto M, Akira S, Sun SC. Wu X, et al. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20836-41. doi: 10.1073/pnas.0906547106. Epub 2009 Nov 19. Proc Natl Acad Sci U S A. 2009. PMID: 19926860 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical