Decreased brain activation during a working memory task at rested baseline is associated with vulnerability to sleep deprivation - PubMed (original) (raw)

Decreased brain activation during a working memory task at rested baseline is associated with vulnerability to sleep deprivation

Qiwen Mu et al. Sleep. 2005 Apr.

Abstract

Study objective: To examine whether differences in patterns of brain activation under baseline conditions relate to the differences in sleep-deprivation vulnerability.

Design: Using blood oxygenation level dependent (BOLD) functional magnetic resonance imaging, we scanned 33 healthy young men while they performed the Sternberg working memory task following a normal night of sleep and again following 30 hours of sleep deprivation. From this initial group, based on their Sternberg working memory task performance, we found 10 subjects resilient to sleep deprivation (sleep deprivation-resilient group) and then selected 10 age- and education-matched subjects vulnerable to sleep deprivation (sleep deprivation-vulnerable group).

Setting: Inpatient General Clinical Research Center and outpatient functional magnetic resonance imaging center.

Patients or participants: Data from 10 young men (mean age 27.8 +/- 1.7 years) in the sleep deprivation-resilient group and 10 young men (mean age 28.2 +/- 1.9 years) in the sleep deprivation-vulnerable group were included in the final analyses.

Interventions: None.

Measurements and results: We compared functional magnetic resonance imaging BOLD signal at rested baseline and sleep deprivation states in the 2 groups. As hypothesized, following sleep deprivation, both groups showed significant decreases in global brain activation compared to their rested group baseline. At rested baseline and in the sleep-deprivation state, the sleep deprivation-resilient group had significantly more brain activation than did the sleep deprivation-vulnerable group. There were also differences in functional circuits within and between groups in response to sleep deprivation.

Conclusions: These preliminary data suggest that patterns of brain activation during the Sternberg working memory task at the rested baseline and the sleep-deprivation state, differ across individuals as a function of their sleep-deprivation vulnerability.

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Comment in

Brain activation patterns and individual differences in working memory impairment during sleep deprivation.
Van Dongen HP. Van Dongen HP. Sleep. 2005 Apr;28(4):386-8. Sleep. 2005. PMID: 16171281 No abstract available.

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Decreased brain activation during a working memory task at rested baseline is associated with vulnerability to sleep deprivation - PubMed (original) (raw)