The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis - PubMed (original) (raw)
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doi: 10.1038/nrc1713.
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- PMID: 16175178
- DOI: 10.1038/nrc1713
Review
The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis
Rosa A Cardone et al. Nat Rev Cancer. 2005 Oct.
Abstract
Recent research has highlighted the fundamental role of the tumour's extracellular metabolic microenvironment in malignant invasion. This microenvironment is acidified primarily by the tumour-cell Na(+)/H(+) exchanger NHE1 and the H(+)/lactate cotransporter, which are activated in cancer cells. NHE1 also regulates formation of invadopodia - cell structures that mediate tumour cell migration and invasion. How do these alterations of the metabolic microenvironment and cell invasiveness contribute to tumour formation and progression?
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