Enzyme immunoassay (EIA)/enzyme-linked immunosorbent assay (ELISA) - PubMed (original) (raw)

. 2005 Dec;51(12):2415-8.

doi: 10.1373/clinchem.2005.051532. Epub 2005 Sep 22.

Affiliations

• PMID: 16179424
• DOI: 10.1373/clinchem.2005.051532

Enzyme immunoassay (EIA)/enzyme-linked immunosorbent assay (ELISA)

Rudolf M Lequin. Clin Chem. 2005 Dec.

Abstract

This brief note addresses the historical background of the invention of the enzyme immunoassay (EIA) and enzyme-linked immunosorbent assay (ELISA). These assays were developed independently and simultaneously by the research group of Peter Perlmann and Eva Engvall at Stockholm University in Sweden and by the research group of Anton Schuurs and Bauke van Weemen in The Netherlands. Today, fully automated instruments in medical laboratories around the world use the immunoassay principle with an enzyme as the reporter label for routine measurements of innumerable analytes in patient samples. The impact of EIA/ELISA is reflected in the overwhelmingly large number of times it has appeared as a keyword in the literature since the 1970s. Clinicians and their patients, medical laboratories, in vitro diagnostics manufacturers, and worldwide healthcare systems owe much to these four inventors.

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Comment in

• Perspective on the historical note on EIA/ELISA by Dr. R.M. Lequin.
  Engvall E. Engvall E. Clin Chem. 2005 Dec;51(12):2225. doi: 10.1373/clinchem.2005.059618. Clin Chem. 2005. PMID: 16306091 No abstract available.
• The rise of EIA/ELISA.
  van Weemen BK. van Weemen BK. Clin Chem. 2005 Dec;51(12):2226. doi: 10.1373/clinchem.2005.059626. Clin Chem. 2005. PMID: 16306092 No abstract available.
• Historical background of the invention of EIA and ELISA.
  Avrameas S. Avrameas S. Clin Chem. 2006 Jul;52(7):1430-1; author reply 1431. doi: 10.1373/clinchem.2006.069724. Clin Chem. 2006. PMID: 16798968 No abstract available.

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