A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility - PubMed (original) (raw)

. 2005 Oct;37(10):1113-8.

doi: 10.1038/ng1646. Epub 2005 Sep 25.

Nick Patterson, Philip L De Jager, Gavin J McDonald, Alicja Waliszewska, Arti Tandon, Robin R Lincoln, Cari DeLoa, Scott A Fruhan, Philippe Cabre, Odile Bera, Gilbert Semana, M Ann Kelly, David A Francis, Kristin Ardlie, Omar Khan, Bruce A C Cree, Stephen L Hauser, Jorge R Oksenberg, David A Hafler

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A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

David Reich et al. Nat Genet. 2005 Oct.

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Abstract

Multiple sclerosis is a common disease with proven heritability, but, despite large-scale attempts, no underlying risk genes have been identified. Traditional linkage scans have so far identified only one risk haplotype for multiple sclerosis (at HLA on chromosome 6), which explains only a fraction of the increased risk to siblings. Association scans such as admixture mapping have much more power, in principle, to find the weak factors that must explain most of the disease risk. We describe here the first high-powered admixture scan, focusing on 605 African American cases and 1,043 African American controls, and report a locus on chromosome 1 that is significantly associated with multiple sclerosis.

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