Prediction of novel and analogous folds using fragment assembly and fold recognition - PubMed (original) (raw)

. 2005:61 Suppl 7:143-151.

doi: 10.1002/prot.20731.

Affiliations

• PMID: 16187356
• DOI: 10.1002/prot.20731

Prediction of novel and analogous folds using fragment assembly and fold recognition

D T Jones et al. Proteins. 2005.

Abstract

A number of new and newly improved methods for predicting protein structure developed by the Jones-University College London group were used to make predictions for the CASP6 experiment. Structures were predicted with a combination of fold recognition methods (mGenTHREADER, nFOLD, and THREADER) and a substantially enhanced version of FRAGFOLD, our fragment assembly method. Attempts at automatic domain parsing were made using DomPred and DomSSEA, which are based on a secondary structure parsing algorithm and additionally for DomPred, a simple local sequence alignment scoring function. Disorder prediction was carried out using a new SVM-based version of DISOPRED. Attempts were also made at domain docking and "microdomain" folding in order to build complete chain models for some targets.

2005 Wiley-Liss, Inc.

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References

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