The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia - PubMed (original) (raw)
The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia
H Ashdown et al. Mol Psychiatry. 2006 Jan.
Abstract
Maternal infections with bacterial or viral agents during pregnancy are associated with an increased incidence of schizophrenia in the offspring at adulthood although little is known about the mechanism by which maternal infection might affect fetal neurodevelopment. Exposure of pregnant rodents to the bacterial endotoxin, lipopolysaccharide (LPS), results in behavioral deficits in the adult offspring that are relevant to schizophrenia. It is however unknown whether these effects are due to the direct action of the inflammatory stimulus on the developing fetus, or due to secondary immune mediators (cytokines) activated at maternal/fetal sites. In this study we sought to elucidate the site of action of LPS, following a single intraperitoneal (i.p.) injection, in pregnant rats at gestation day 18. Animals received 5 muCi of iodinated LPS ((125)I-LPS) and its distribution was assessed in maternal/fetal tissues (1-8 h). In addition, induction of the inflammatory cytokines, TNF-alpha, IL-1beta and IL-6, was measured in maternal/fetal tissues following maternal LPS challenge (0.05 mg/kg, i.p.) (2-8 h). (125)I-LPS was detected in maternal tissues and placenta, but not the fetus. This distribution was accompanied by significant increases in TNF-alpha, IL-1beta and IL-6 in maternal plasma and placenta, but not in fetal liver or brain. A significant increase in IL-1beta was however detected in fetal plasma, possibly due to transfer from the maternal circulation or placenta. Collectively, these data suggest that effects of maternal LPS exposure on the developing fetal brain are not mediated by the direct action of LPS, but via indirect actions at the level of the maternal circulation or placenta.
Similar articles
- Erythropoietin attenuates lipopolysaccharide-induced white matter injury in the neonatal rat brain.
Kumral A, Baskin H, Yesilirmak DC, Ergur BU, Aykan S, Genc S, Genc K, Yilmaz O, Tugyan K, Giray O, Duman N, Ozkan H. Kumral A, et al. Neonatology. 2007;92(4):269-78. doi: 10.1159/000105493. Epub 2007 Jul 11. Neonatology. 2007. PMID: 17627093 - Prophylactic maternal n-acetylcysteine before lipopolysaccharide suppresses fetal inflammatory cytokine responses.
Beloosesky R, Weiner Z, Khativ N, Maravi N, Mandel R, Boles J, Ross MG, Itskovitz-Eldor J. Beloosesky R, et al. Am J Obstet Gynecol. 2009 Jun;200(6):665.e1-5. doi: 10.1016/j.ajog.2009.01.032. Epub 2009 Apr 3. Am J Obstet Gynecol. 2009. PMID: 19344884 - Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia.
Meyer U, Feldon J, Schedlowski M, Yee BK. Meyer U, et al. Neurosci Biobehav Rev. 2005;29(6):913-47. doi: 10.1016/j.neubiorev.2004.10.012. Neurosci Biobehav Rev. 2005. PMID: 15964075 Review. - Recent progress in animal modeling of immune inflammatory processes in schizophrenia: implication of specific cytokines.
Nawa H, Takei N. Nawa H, et al. Neurosci Res. 2006 Sep;56(1):2-13. doi: 10.1016/j.neures.2006.06.002. Epub 2006 Jul 11. Neurosci Res. 2006. PMID: 16837094 Review.
Cited by
- Viral infections in etiology of mental disorders: a broad analysis of cytokine profile similarities - a narrative review.
Lorkiewicz P, Waszkiewicz N. Lorkiewicz P, et al. Front Cell Infect Microbiol. 2024 Aug 14;14:1423739. doi: 10.3389/fcimb.2024.1423739. eCollection 2024. Front Cell Infect Microbiol. 2024. PMID: 39206043 Free PMC article. Review. - Disruption of Intranasal GnRH Neuronal Migration Route into the Brain Induced by Proinflammatory Cytokine IL-6: Ex Vivo and In Vivo Rodent Models.
Sharova V, Ignatiuk V, Izvolskaia M, Zakharova L. Sharova V, et al. Int J Mol Sci. 2023 Nov 5;24(21):15983. doi: 10.3390/ijms242115983. Int J Mol Sci. 2023. PMID: 37958965 Free PMC article. - Abnormal expression of miR-3653-3p, caspase 1, IL-1β in peripheral blood of schizophrenia.
Zhao XL, Liu YL, Long Q, Zhang YQ, You X, Guo ZY, Cao X, Yu L, Qin FY, Teng ZW, Zeng Y. Zhao XL, et al. BMC Psychiatry. 2023 Nov 9;23(1):822. doi: 10.1186/s12888-023-05182-0. BMC Psychiatry. 2023. PMID: 37946206 Free PMC article. - Counting the Toll of Inflammation on Schizophrenia-A Potential Role for Toll-like Receptors.
Patlola SR, Donohoe G, McKernan DP. Patlola SR, et al. Biomolecules. 2023 Jul 30;13(8):1188. doi: 10.3390/biom13081188. Biomolecules. 2023. PMID: 37627253 Free PMC article. Review. - Cyclophilin A as a Pro-Inflammatory Factor Exhibits Embryotoxic and Teratogenic Effects during Fetal Organogenesis.
Kalinina A, Semenova M, Bruter A, Varlamova E, Kubekina M, Pavlenko N, Silaeva Y, Deikin A, Antoshina E, Gorkova T, Trukhanova L, Salmina A, Novikova S, Voronkov D, Kazansky D, Khromykh L. Kalinina A, et al. Int J Mol Sci. 2023 Jul 10;24(14):11279. doi: 10.3390/ijms241411279. Int J Mol Sci. 2023. PMID: 37511039 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical