Breakdown of cortical effective connectivity during sleep - PubMed (original) (raw)
. 2005 Sep 30;309(5744):2228-32.
doi: 10.1126/science.1117256.
Affiliations
- PMID: 16195466
- DOI: 10.1126/science.1117256
Breakdown of cortical effective connectivity during sleep
Marcello Massimini et al. Science. 2005.
Abstract
When we fall asleep, consciousness fades yet the brain remains active. Why is this so? To investigate whether changes in cortical information transmission play a role, we used transcranial magnetic stimulation together with high-density electroencephalography and asked how the activation of one cortical area (the premotor area) is transmitted to the rest of the brain. During quiet wakefulness, an initial response (approximately 15 milliseconds) at the stimulation site was followed by a sequence of waves that moved to connected cortical areas several centimeters away. During non-rapid eye movement sleep, the initial response was stronger but was rapidly extinguished and did not propagate beyond the stimulation site. Thus, the fading of consciousness during certain stages of sleep may be related to a breakdown in cortical effective connectivity.
Comment in
- Neuroscience. Neural communication breaks down as consciousness fades and sleep sets in.
Miller G. Miller G. Science. 2005 Sep 30;309(5744):2148-9. doi: 10.1126/science.309.5744.2148a. Science. 2005. PMID: 16195435 No abstract available. - Cognitive unbinding in sleep and anesthesia.
Mashour GA. Mashour GA. Science. 2005 Dec 16;310(5755):1768-9; author reply 1768-9. doi: 10.1126/science.310.5755.1768b. Science. 2005. PMID: 16357245 No abstract available.
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