On the road to cancer: aneuploidy and the mitotic checkpoint - PubMed (original) (raw)
Review
doi: 10.1038/nrc1714.
Affiliations
- PMID: 16195750
- DOI: 10.1038/nrc1714
Review
On the road to cancer: aneuploidy and the mitotic checkpoint
Geert J P L Kops et al. Nat Rev Cancer. 2005 Oct.
Abstract
Abnormal chromosome content - also known as aneuploidy - is the most common characteristic of human solid tumours. It has therefore been proposed that aneuploidy contributes to, or even drives, tumour development. The mitotic checkpoint guards against chromosome mis-segregation by delaying cell-cycle progression through mitosis until all chromosomes have successfully made spindle-microtubule attachments. Defects in the mitotic checkpoint generate aneuploidy and might facilitate tumorigenesis, but more severe disabling of checkpoint signalling is a possible anticancer strategy.
Similar articles
- How mitotic errors contribute to karyotypic diversity in cancer.
Nicholson JM, Cimini D. Nicholson JM, et al. Adv Cancer Res. 2011;112:43-75. doi: 10.1016/B978-0-12-387688-1.00003-X. Adv Cancer Res. 2011. PMID: 21925301 Review. - The spindle assembly checkpoint: preventing chromosome mis-segregation during mitosis and meiosis.
Malmanche N, Maia A, Sunkel CE. Malmanche N, et al. FEBS Lett. 2006 May 22;580(12):2888-95. doi: 10.1016/j.febslet.2006.03.081. Epub 2006 Apr 7. FEBS Lett. 2006. PMID: 16631173 Review. - Causes of Chromosomal Instability.
Bastians H. Bastians H. Recent Results Cancer Res. 2015;200:95-113. doi: 10.1007/978-3-319-20291-4_5. Recent Results Cancer Res. 2015. PMID: 26376874 Review. - Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis.
Holland AJ, Cleveland DW. Holland AJ, et al. Nat Rev Mol Cell Biol. 2009 Jul;10(7):478-87. doi: 10.1038/nrm2718. Nat Rev Mol Cell Biol. 2009. PMID: 19546858 Free PMC article. Review. - Preventing aneuploidy: the contribution of mitotic checkpoint proteins.
Suijkerbuijk SJ, Kops GJ. Suijkerbuijk SJ, et al. Biochim Biophys Acta. 2008 Sep;1786(1):24-31. doi: 10.1016/j.bbcan.2008.04.001. Epub 2008 Apr 22. Biochim Biophys Acta. 2008. PMID: 18472014 Review.
Cited by
- Weighted frequent gene co-expression network mining to identify genes involved in genome stability.
Zhang J, Lu K, Xiang Y, Islam M, Kotian S, Kais Z, Lee C, Arora M, Liu HW, Parvin JD, Huang K. Zhang J, et al. PLoS Comput Biol. 2012;8(8):e1002656. doi: 10.1371/journal.pcbi.1002656. Epub 2012 Aug 30. PLoS Comput Biol. 2012. PMID: 22956898 Free PMC article. - ATRX contributes to epigenetic asymmetry and silencing of major satellite transcripts in the maternal genome of the mouse embryo.
De La Fuente R, Baumann C, Viveiros MM. De La Fuente R, et al. Development. 2015 May 15;142(10):1806-17. doi: 10.1242/dev.118927. Epub 2015 Apr 29. Development. 2015. PMID: 25926359 Free PMC article. - Causes and consequences of aneuploidy in cancer.
Gordon DJ, Resio B, Pellman D. Gordon DJ, et al. Nat Rev Genet. 2012 Jan 24;13(3):189-203. doi: 10.1038/nrg3123. Nat Rev Genet. 2012. PMID: 22269907 Review. - Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability.
Liu X, Zheng H, Qu CK. Liu X, et al. Cancer Res. 2012 Oct 15;72(20):5296-306. doi: 10.1158/0008-5472.CAN-12-1495. Epub 2012 Aug 13. Cancer Res. 2012. PMID: 22890240 Free PMC article. - Ectopic Expression of Testis Germ Cell Proteins in Cancer and Its Potential Role in Genomic Instability.
Nielsen AY, Gjerstorff MF. Nielsen AY, et al. Int J Mol Sci. 2016 Jun 6;17(6):890. doi: 10.3390/ijms17060890. Int J Mol Sci. 2016. PMID: 27275820 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources