On the road to cancer: aneuploidy and the mitotic checkpoint - PubMed (original) (raw)
Review
doi: 10.1038/nrc1714.
Affiliations
- PMID: 16195750
- DOI: 10.1038/nrc1714
Review
On the road to cancer: aneuploidy and the mitotic checkpoint
Geert J P L Kops et al. Nat Rev Cancer. 2005 Oct.
Abstract
Abnormal chromosome content - also known as aneuploidy - is the most common characteristic of human solid tumours. It has therefore been proposed that aneuploidy contributes to, or even drives, tumour development. The mitotic checkpoint guards against chromosome mis-segregation by delaying cell-cycle progression through mitosis until all chromosomes have successfully made spindle-microtubule attachments. Defects in the mitotic checkpoint generate aneuploidy and might facilitate tumorigenesis, but more severe disabling of checkpoint signalling is a possible anticancer strategy.
Similar articles
- How mitotic errors contribute to karyotypic diversity in cancer.
Nicholson JM, Cimini D. Nicholson JM, et al. Adv Cancer Res. 2011;112:43-75. doi: 10.1016/B978-0-12-387688-1.00003-X. Adv Cancer Res. 2011. PMID: 21925301 Review. - The spindle assembly checkpoint: preventing chromosome mis-segregation during mitosis and meiosis.
Malmanche N, Maia A, Sunkel CE. Malmanche N, et al. FEBS Lett. 2006 May 22;580(12):2888-95. doi: 10.1016/j.febslet.2006.03.081. Epub 2006 Apr 7. FEBS Lett. 2006. PMID: 16631173 Review. - Causes of Chromosomal Instability.
Bastians H. Bastians H. Recent Results Cancer Res. 2015;200:95-113. doi: 10.1007/978-3-319-20291-4_5. Recent Results Cancer Res. 2015. PMID: 26376874 Review. - Preventing aneuploidy: the contribution of mitotic checkpoint proteins.
Suijkerbuijk SJ, Kops GJ. Suijkerbuijk SJ, et al. Biochim Biophys Acta. 2008 Sep;1786(1):24-31. doi: 10.1016/j.bbcan.2008.04.001. Epub 2008 Apr 22. Biochim Biophys Acta. 2008. PMID: 18472014 Review. - Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis.
Holland AJ, Cleveland DW. Holland AJ, et al. Nat Rev Mol Cell Biol. 2009 Jul;10(7):478-87. doi: 10.1038/nrm2718. Nat Rev Mol Cell Biol. 2009. PMID: 19546858 Free PMC article. Review.
Cited by
- Role of TRIP13 in human cancer development.
Chen C, Li P, Fan G, Yang E, Jing S, Shi Y, Gong Y, Zhang L, Wang Z. Chen C, et al. Mol Biol Rep. 2024 Oct 22;51(1):1088. doi: 10.1007/s11033-024-10012-x. Mol Biol Rep. 2024. PMID: 39436503 Review. - p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver.
Kurinna S, Stratton SA, Coban Z, Schumacher JM, Grompe M, Duncan AW, Barton MC. Kurinna S, et al. Hepatology. 2013 May;57(5):2004-13. doi: 10.1002/hep.26233. Epub 2013 Feb 15. Hepatology. 2013. PMID: 23300120 Free PMC article. - 2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells.
Zasadil LM, Britigan EM, Weaver BA. Zasadil LM, et al. Semin Cell Dev Biol. 2013 Apr;24(4):370-9. doi: 10.1016/j.semcdb.2013.02.001. Epub 2013 Feb 13. Semin Cell Dev Biol. 2013. PMID: 23416057 Free PMC article. - CENPE Inhibition Leads to Mitotic Catastrophe and DNA Damage in Medulloblastoma Cells.
Iegiani G, Gai M, Di Cunto F, Pallavicini G. Iegiani G, et al. Cancers (Basel). 2021 Mar 1;13(5):1028. doi: 10.3390/cancers13051028. Cancers (Basel). 2021. PMID: 33804489 Free PMC article. - Complications dawn for kinetochore regulation by Aurora.
Nannas NJ, Murray AW. Nannas NJ, et al. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):15972-3. doi: 10.1073/pnas.1214115109. Epub 2012 Sep 18. Proc Natl Acad Sci U S A. 2012. PMID: 22991465 Free PMC article. No abstract available.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources