Cognitive deficits following traumatic brain injury produced by controlled cortical impact - PubMed (original) (raw)

. 1992 Spring;9(1):11-20.

doi: 10.1089/neu.1992.9.11.

Affiliations

• PMID: 1619672
• DOI: 10.1089/neu.1992.9.11

Cognitive deficits following traumatic brain injury produced by controlled cortical impact

R J Hamm et al. J Neurotrauma. 1992 Spring.

Abstract

Traumatic brain injury produces significant cognitive deficits in humans. This experiment used a controlled cortical impact model of experimental brain injury to examine the effects of brain injury on spatial learning and memory using the Morris water maze task. Rats (n = 8) were injured at a moderate level of cortical impact injury (6 m/sec, 1.5-2.0 mm deformation). Eight additional rats served as a sham-injured control group. Morris water maze performance was assessed on days 11-15 and 30-34 following injury. Results revealed that brain-injured rats exhibited significant deficits (p less than 0.05) in maze performance at both testing intervals. Since the Morris water maze task is particularly sensitive to hippocampal dysfunction, the results of the present experiment support the hypothesis that the hippocampus is preferentially vulnerable to damage following traumatic brain injury. These results demonstrate that controlled cortical impact brain injury produces enduring cognitive deficits analogous to those observed after human brain injury.

PubMed Disclaimer

Similar articles

• Increased anticholinergic sensitivity following closed skull impact and controlled cortical impact traumatic brain injury in the rat.
  Dixon CE, Hamm RJ, Taft WC, Hayes RL. Dixon CE, et al. J Neurotrauma. 1994 Jun;11(3):275-87. doi: 10.1089/neu.1994.11.275. J Neurotrauma. 1994. PMID: 7996582
• One-year study of spatial memory performance, brain morphology, and cholinergic markers after moderate controlled cortical impact in rats.
  Dixon CE, Kochanek PM, Yan HQ, Schiding JK, Griffith RG, Baum E, Marion DW, DeKosky ST. Dixon CE, et al. J Neurotrauma. 1999 Feb;16(2):109-22. doi: 10.1089/neu.1999.16.109. J Neurotrauma. 1999. PMID: 10098956
• Applications of the Morris water maze in translational traumatic brain injury research.
  Tucker LB, Velosky AG, McCabe JT. Tucker LB, et al. Neurosci Biobehav Rev. 2018 May;88:187-200. doi: 10.1016/j.neubiorev.2018.03.010. Epub 2018 Mar 13. Neurosci Biobehav Rev. 2018. PMID: 29545166 Review.
• Assessment of cognitive function following magnesium therapy in the traumatically injured brain.
  Hoane MR. Hoane MR. Magnes Res. 2007 Dec;20(4):229-36. Magnes Res. 2007. PMID: 18271492 Review.

Cited by

• Neurogenic and neuro-protective potential of a novel subpopulation of peripheral blood-derived CD133+ ABCG2+CXCR4+ mesenchymal stem cells: development of autologous cell-based therapeutics for traumatic brain injury.
  Nichols JE, Niles JA, DeWitt D, Prough D, Parsley M, Vega S, Cantu A, Lee E, Cortiella J. Nichols JE, et al. Stem Cell Res Ther. 2013 Jan 6;4(1):3. doi: 10.1186/scrt151. Stem Cell Res Ther. 2013. PMID: 23290300 Free PMC article.
• Severity-Dependent Long-Term Spatial Learning-Memory Impairment in a Mouse Model of Traumatic Brain Injury.
  An C, Jiang X, Pu H, Hong D, Zhang W, Hu X, Gao Y. An C, et al. Transl Stroke Res. 2016 Dec;7(6):512-520. doi: 10.1007/s12975-016-0483-5. Epub 2016 Aug 18. Transl Stroke Res. 2016. PMID: 27539574
• Role of Microvascular Disruption in Brain Damage from Traumatic Brain Injury.
  Logsdon AF, Lucke-Wold BP, Turner RC, Huber JD, Rosen CL, Simpkins JW. Logsdon AF, et al. Compr Physiol. 2015 Jul 1;5(3):1147-60. doi: 10.1002/cphy.c140057. Compr Physiol. 2015. PMID: 26140712 Free PMC article. Review.
• Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury.
  Ji J, Kline AE, Amoscato A, Samhan-Arias AK, Sparvero LJ, Tyurin VA, Tyurina YY, Fink B, Manole MD, Puccio AM, Okonkwo DO, Cheng JP, Alexander H, Clark RS, Kochanek PM, Wipf P, Kagan VE, Bayır H. Ji J, et al. Nat Neurosci. 2012 Oct;15(10):1407-13. doi: 10.1038/nn.3195. Epub 2012 Aug 26. Nat Neurosci. 2012. PMID: 22922784 Free PMC article.
• Evaluation of a combined therapeutic regimen of 8-OH-DPAT and environmental enrichment after experimental traumatic brain injury.
  Kline AE, McAloon RL, Henderson KA, Bansal UK, Ganti BM, Ahmed RH, Gibbs RB, Sozda CN. Kline AE, et al. J Neurotrauma. 2010 Nov;27(11):2021-32. doi: 10.1089/neu.2010.1535. Epub 2010 Oct 28. J Neurotrauma. 2010. PMID: 21028935 Free PMC article.

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Atypon

• Other Literature Sources

  • The Lens - Patent Citations Database