Don't lose heart--therapeutic value of apoptosis prevention in the treatment of cardiovascular disease - PubMed (original) (raw)

Review

Don't lose heart--therapeutic value of apoptosis prevention in the treatment of cardiovascular disease

Janice L V Reeve et al. J Cell Mol Med. 2005 Jul-Sep.

Abstract

Cardiovascular disease is a leading cause of death worldwide. Loss of function or death of cardiomyocytes is a major contributing factor to these diseases. Cell death in conditions such as heart failure and myocardial infarction is associated with apoptosis. Apoptotic pathways have been well studied in non-myocytes and it is thought that similar pathways exist in cardiomyocytes. These pathways include death initiated by ligation of membrane-bound death receptors, release of pro-apoptotic factors from mitochondria or stress at the endoplasmic reticulum. The key regulators of apoptosis include inhibitors of caspases (IAPs), the Bcl-2 family of proteins, growth factors, stress proteins, calcium and oxidants. The highly organized and predictive nature of apoptotic signaling means it is amenable to manipulation. A thorough understanding of the apoptotic process would facilitate intervention at the most suitable points, alleviating myocardium decline and dysfunction. This review summarizes the mechanisms underlying apoptosis and the mediators/regulators involved in these signaling pathways. We also discuss how the potential therapeutic value of these molecules could be harnessed.

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References

1. 1. Lockshin RA, Zakeri Z. Caspase‐independent cell deaths. Curr Opin Cell Biol. 2002; 14: 727–33. - PubMed
2. 1. Samali A, Zhivotovsky B, Jones D, Nagata S, Orrenius S. Apoptosis: cell death defined by caspase activation. Cell Death Differ. 1999; 6: 495–6. - PubMed
3. 1. Fisher SA, Langille BL, Srivastava D. Apoptosis during cardiovascular development. Circ Res. 2000; 87: 856–64. - PubMed
4. 1. James TN. Normal and abnormal consequences of apoptosis in the human heart. From postnatal morphogenesis to paroxysmal arrhythmias. Circulation 1994; 90: 556–73. - PubMed
5. 1. Gill C, Mestril R, Samali A. Losing heart: the role of apoptosis in heart disease ‐ a novel therapeutic target Faseb J. 2002; 16: 135–46. - PubMed

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