The caudal-related protein cdx2 promotes trophoblast differentiation of mouse embryonic stem cells - PubMed (original) (raw)

The caudal-related protein cdx2 promotes trophoblast differentiation of mouse embryonic stem cells

Elena Tolkunova et al. Stem Cells. 2006 Jan.

Abstract

Besides holding great promise in clinics, embryonic stem (ES) cells represent a valuable tool for studying regulation of early developmental processes, such as cell differentiation in preimplantation embryos. The caudal-related homeobox protein Cdx2 is a transcriptional regulator essential for trophoblast lineage, functioning as early as implantation. Using an inducible system, we show that gain of Cdx2 function in ES cells triggers trophoblast-like morphological differentiation, accompanied by ploidy increase, onset of expression of trophoblast-specific markers, and loss of pluripotency-associated gene expression. These data provide an insight into the genetic network that controls lineage specification and functioning in early mammalian development.

PubMed Disclaimer

Similar articles

• Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2.
  Ralston A, Cox BJ, Nishioka N, Sasaki H, Chea E, Rugg-Gunn P, Guo G, Robson P, Draper JS, Rossant J. Ralston A, et al. Development. 2010 Feb;137(3):395-403. doi: 10.1242/dev.038828. Development. 2010. PMID: 20081188
• The transcription factor TCFAP2C/AP-2gamma cooperates with CDX2 to maintain trophectoderm formation.
  Kuckenberg P, Buhl S, Woynecki T, van Fürden B, Tolkunova E, Seiffe F, Moser M, Tomilin A, Winterhager E, Schorle H. Kuckenberg P, et al. Mol Cell Biol. 2010 Jul;30(13):3310-20. doi: 10.1128/MCB.01215-09. Epub 2010 Apr 19. Mol Cell Biol. 2010. PMID: 20404091 Free PMC article.
• Collagen IV induces trophoectoderm differentiation of mouse embryonic stem cells.
  Schenke-Layland K, Angelis E, Rhodes KE, Heydarkhan-Hagvall S, Mikkola HK, Maclellan WR. Schenke-Layland K, et al. Stem Cells. 2007 Jun;25(6):1529-38. doi: 10.1634/stemcells.2006-0729. Epub 2007 Mar 15. Stem Cells. 2007. PMID: 17363553
• Transcriptional regulators of the trophoblast lineage in mammals with hemochorial placentation.
  Knott JG, Paul S. Knott JG, et al. Reproduction. 2014 Dec;148(6):R121-36. doi: 10.1530/REP-14-0072. Epub 2014 Sep 4. Reproduction. 2014. PMID: 25190503 Free PMC article. Review.
• Trophoblast gene expression: transcription factors in the specification of early trophoblast.
  Roberts RM, Ezashi T, Das P. Roberts RM, et al. Reprod Biol Endocrinol. 2004 Jul 5;2:47. doi: 10.1186/1477-7827-2-47. Reprod Biol Endocrinol. 2004. PMID: 15236655 Free PMC article. Review.

Cited by

• Transcription coactivator Cited1 acts as an inducer of trophoblast-like state from mouse embryonic stem cells through the activation of BMP signaling.
  Xu Y, Luo X, Fang Z, Zheng X, Zeng Y, Zhu C, Gu J, Tang F, Hu Y, Hu G, Jin Y, Li H. Xu Y, et al. Cell Death Dis. 2018 Sep 11;9(9):924. doi: 10.1038/s41419-018-0991-1. Cell Death Dis. 2018. PMID: 30206204 Free PMC article.
• Transcriptional reprogramming and chromatin remodeling accompanies Oct4 and Nanog silencing in mouse trophoblast lineage.
  Carey TS, Choi I, Wilson CA, Floer M, Knott JG. Carey TS, et al. Stem Cells Dev. 2014 Feb 1;23(3):219-29. doi: 10.1089/scd.2013.0328. Epub 2013 Nov 7. Stem Cells Dev. 2014. PMID: 24059348 Free PMC article.
• Chromatin dynamics in the regulation of cell fate allocation during early embryogenesis.
  Burton A, Torres-Padilla ME. Burton A, et al. Nat Rev Mol Cell Biol. 2014 Nov;15(11):723-34. doi: 10.1038/nrm3885. Epub 2014 Oct 10. Nat Rev Mol Cell Biol. 2014. PMID: 25303116 Review.
• Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency.
  Chamberlain SJ, Yee D, Magnuson T. Chamberlain SJ, et al. Stem Cells. 2008 Jun;26(6):1496-505. doi: 10.1634/stemcells.2008-0102. Epub 2008 Apr 10. Stem Cells. 2008. PMID: 18403752 Free PMC article.
• The pursuit of ES cell lines of domesticated ungulates.
  Talbot NC, Blomberg Le Ann. Talbot NC, et al. Stem Cell Rev. 2008 Sep;4(3):235-54. doi: 10.1007/s12015-008-9026-0. Epub 2008 Jul 9. Stem Cell Rev. 2008. PMID: 18612851 Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Research Materials

  • NCI CPTC Antibody Characterization Program