Characterization of the reconstructed 1918 Spanish influenza pandemic virus - PubMed (original) (raw)

. 2005 Oct 7;310(5745):77-80.

doi: 10.1126/science.1119392.

Affiliations

• PMID: 16210530
• DOI: 10.1126/science.1119392

Characterization of the reconstructed 1918 Spanish influenza pandemic virus

Terrence M Tumpey et al. Science. 2005.

Abstract

The pandemic influenza virus of 1918-1919 killed an estimated 20 to 50 million people worldwide. With the recent availability of the complete 1918 influenza virus coding sequence, we used reverse genetics to generate an influenza virus bearing all eight gene segments of the pandemic virus to study the properties associated with its extraordinary virulence. In stark contrast to contemporary human influenza H1N1 viruses, the 1918 pandemic virus had the ability to replicate in the absence of trypsin, caused death in mice and embryonated chicken eggs, and displayed a high-growth phenotype in human bronchial epithelial cells. Moreover, the coordinated expression of the 1918 virus genes most certainly confers the unique high-virulence phenotype observed with this pandemic virus.

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Comment in

• 1918 flu and responsible science.
  Sharp PA. Sharp PA. Science. 2005 Oct 7;310(5745):17. doi: 10.1126/science.310.5745.17. Science. 2005. PMID: 16210500 No abstract available.
• Virology. Resurrected influenza virus yields secrets of deadly 1918 pandemic.
  Kaiser J. Kaiser J. Science. 2005 Oct 7;310(5745):28-9. doi: 10.1126/science.310.5745.28. Science. 2005. PMID: 16210501 No abstract available.
• Better never than late.
  Kennedy D. Kennedy D. Science. 2005 Oct 14;310(5746):195. doi: 10.1126/science.310.5746.195. Science. 2005. PMID: 16223986 No abstract available.
• Advising on publication.
  Simonson S. Simonson S. Science. 2006 Jan 20;311(5759):336-7. doi: 10.1126/science.311.5759.336. Science. 2006. PMID: 16424324 No abstract available.
• Vaccine against Spanish flu.
  Jensenius JC. Jensenius JC. Science. 2006 Mar 17;311(5767):1552; author reply 1552. doi: 10.1126/science.311.5767.1552b. Science. 2006. PMID: 16543439 No abstract available.

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