Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling - PubMed (original) (raw)
Review
. 2006 Mar 10;312(5):630-41.
doi: 10.1016/j.yexcr.2005.09.002. Epub 2005 Oct 12.
Affiliations
- PMID: 16225862
- DOI: 10.1016/j.yexcr.2005.09.002
Review
Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling
Lauri Eklund et al. Exp Cell Res. 2006.
Abstract
Angiopoietins are ligands of the Tie2 receptor that control angiogenic remodeling in a context-dependent manner. Tie signaling is involved in multiple steps of the angiogenic remodeling process during development, including destabilization of existing vessels, endothelial cell migration, tube formation and the subsequent stabilization of newly formed tubes by mesenchymal cells. Beyond this critical role in blood vessel development, recent studies suggest a wider role for Tie2 and angiopoietins in lymphangiogenesis and the development of the hematopoietic system, as well as a possible role in the regulation of certain non-endothelial cells. The outcome of Tie signaling depends on which vascular bed is involved, and crosstalk between different VEGFs has an important modulating effect on the properties of the angiopoietins. Signaling through the Tie1 receptor is not well understood, but Tie1 may have both angiopoietin-dependent and ligand-independent functions. Changes in the expression of Tie receptors and angiopoietins occur in many pathological conditions, and mutations in the Tie2 gene are found in familial cases of vascular disease.
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