Macrophage polarization comes of age - PubMed (original) (raw)

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Macrophage polarization comes of age

Alberto Mantovani et al. Immunity. 2005 Oct.

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Abstract

Functional polarization of macrophages into M1 or M2 cells is an operationally useful, simplified conceptual framework describing the plasticity of mononuclear phagocytes. Genetic approaches have begun to shed new light on mechanisms underlying macrophage polarization and on the actual in vivo significance of polarized M2 cells ( [this issue of Immunity]).

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• SHIP represses the generation of alternatively activated macrophages.
  Rauh MJ, Ho V, Pereira C, Sham A, Sly LM, Lam V, Huxham L, Minchinton AI, Mui A, Krystal G. Rauh MJ, et al. Immunity. 2005 Oct;23(4):361-74. doi: 10.1016/j.immuni.2005.09.003. Immunity. 2005. PMID: 16226502

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