Molecular structure of adhesin domains in Escherichia coli fimbriae - PubMed (original) (raw)
Review
Molecular structure of adhesin domains in Escherichia coli fimbriae
Benita Westerlund-Wikström et al. Int J Med Microbiol. 2005 Oct.
Abstract
Crystal structures of FimH, PapG, GafD, and DraE fimbrial adhesin subunits or lectin domains have been resolved. These adhesins bind to different targets and are only distantly related in amino acid sequence. The overall structures of the fimbrial lectins, however, appear similar, suggesting that the fimbrial lectins have diverged from a common scaffold. FimH, PapG and GafD are two-domain structures connected by a flexible linker, and the N-terminal adhesin domains have an elongated beta-barrel jelly roll fold that contains the receptor-binding groove. The adhesin domains differ in disulfide patterns, in size and location of the ligand-binding groove, as well as in mechanism of receptor binding. Minor sequence variations that can be either distant from, near to, or at the ligand-binding groove have profound effects on receptor binding by the fimbriae; this is particularly apparent with FimH. The existing structures give insight into the molecular basis of the diversity in fimbrial lectins.
Similar articles
- Valency conversion in the type 1 fimbrial adhesin of Escherichia coli.
Sokurenko EV, Schembri MA, Trintchina E, Kjaergaard K, Hasty DL, Klemm P. Sokurenko EV, et al. Mol Microbiol. 2001 Aug;41(3):675-86. doi: 10.1046/j.1365-2958.2001.02545.x. Mol Microbiol. 2001. PMID: 11532135 - The fimbrial adhesin F17-G of enterotoxigenic Escherichia coli has an immunoglobulin-like lectin domain that binds N-acetylglucosamine.
Buts L, Bouckaert J, De Genst E, Loris R, Oscarson S, Lahmann M, Messens J, Brosens E, Wyns L, De Greve H. Buts L, et al. Mol Microbiol. 2003 Aug;49(3):705-15. doi: 10.1046/j.1365-2958.2003.03600.x. Mol Microbiol. 2003. PMID: 12864853 - Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin.
Bouckaert J, Berglund J, Schembri M, De Genst E, Cools L, Wuhrer M, Hung CS, Pinkner J, Slättegård R, Zavialov A, Choudhury D, Langermann S, Hultgren SJ, Wyns L, Klemm P, Oscarson S, Knight SD, De Greve H. Bouckaert J, et al. Mol Microbiol. 2005 Jan;55(2):441-55. doi: 10.1111/j.1365-2958.2004.04415.x. Mol Microbiol. 2005. PMID: 15659162 - Combining sites of bacterial fimbriae.
De Greve H, Wyns L, Bouckaert J. De Greve H, et al. Curr Opin Struct Biol. 2007 Oct;17(5):506-12. doi: 10.1016/j.sbi.2007.06.011. Epub 2007 Aug 23. Curr Opin Struct Biol. 2007. PMID: 17719218 Review. - Molecular characterization of the Escherichia coli FimH adhesin.
Schembri MA, Kjaergaard K, Sokurenko EV, Klemm P. Schembri MA, et al. J Infect Dis. 2001 Mar 1;183 Suppl 1:S28-31. doi: 10.1086/318847. J Infect Dis. 2001. PMID: 11171009 Review. No abstract available.
Cited by
- Structure of CFA/I fimbriae from enterotoxigenic Escherichia coli.
Li YF, Poole S, Nishio K, Jang K, Rasulova F, McVeigh A, Savarino SJ, Xia D, Bullitt E. Li YF, et al. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10793-8. doi: 10.1073/pnas.0812843106. Epub 2009 Jun 10. Proc Natl Acad Sci U S A. 2009. PMID: 19515814 Free PMC article. - Structural Sampling of Glycan Interaction Profiles Reveals Mucosal Receptors for Fimbrial Adhesins of Enterotoxigenic Escherichia coli.
Lonardi E, Moonens K, Buts L, de Boer AR, Olsson JD, Weiss MS, Fabre E, Guérardel Y, Deelder AM, Oscarson S, Wuhrer M, Bouckaert J. Lonardi E, et al. Biology (Basel). 2013 Jul 1;2(3):894-917. doi: 10.3390/biology2030894. Biology (Basel). 2013. PMID: 24833052 Free PMC article. - Lectin-Glycan Interaction Network-Based Identification of Host Receptors of Microbial Pathogenic Adhesins.
Ielasi FS, Alioscha-Perez M, Donohue D, Claes S, Sahli H, Schols D, Willaert RG. Ielasi FS, et al. mBio. 2016 Jul 12;7(4):e00584-16. doi: 10.1128/mBio.00584-16. mBio. 2016. PMID: 27406561 Free PMC article. - Artificial neural networks trained to detect viral and phage structural proteins.
Seguritan V, Alves N Jr, Arnoult M, Raymond A, Lorimer D, Burgin AB Jr, Salamon P, Segall AM. Seguritan V, et al. PLoS Comput Biol. 2012;8(8):e1002657. doi: 10.1371/journal.pcbi.1002657. Epub 2012 Aug 23. PLoS Comput Biol. 2012. PMID: 22927809 Free PMC article. - Structural Insights into Escherichia coli Shiga Toxin (Stx) Glycosphingolipid Receptors of Porcine Renal Epithelial Cells and Inhibition of Stx-Mediated Cellular Injury Using Neoglycolipid-Spiked Glycovesicles.
Detzner J, Gloerfeld C, Pohlentz G, Legros N, Humpf HU, Mellmann A, Karch H, Müthing J. Detzner J, et al. Microorganisms. 2019 Nov 19;7(11):582. doi: 10.3390/microorganisms7110582. Microorganisms. 2019. PMID: 31752441 Free PMC article.