Molecular pathways in hepatocellular carcinoma - PubMed (original) (raw)

Review

. 2006 Aug 28;240(2):157-69.

doi: 10.1016/j.canlet.2005.08.031. Epub 2005 Oct 17.

Affiliations

• PMID: 16239065
• DOI: 10.1016/j.canlet.2005.08.031

Review

Molecular pathways in hepatocellular carcinoma

Roberta Pang et al. Cancer Lett. 2006.

Abstract

Research over the past decade has unraveled important molecular pathways involved in hepatocellular carcinoma (HCC), and several chromosomal and genetic aberrations have been identified to be responsible for initiation of the carcinogenic process. HBx protein and HCV core protein appear to play a pivotal role in hepatocarcinogenesis related to hepatitis B virus and hepatitis C virus, respectively. These viral oncoproteins allow cells to bypass some of the multi-steps in hepatocarcinogenesis, accounting for the etiological role of the two viruses in HCC. Understanding of the molecular pathways of HCC facilitates the development of novel molecular strategies for chemoprevention and therapy of HCC.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Medical

  • MedlinePlus Health Information

• Miscellaneous

  • NCI CPTAC Assay Portal