Regulation of lung injury and repair by Toll-like receptors and hyaluronan - PubMed (original) (raw)
Comparative Study
. 2005 Nov;11(11):1173-9.
doi: 10.1038/nm1315. Epub 2005 Oct 23.
Jiurong Liang, Juan Fan, Shuang Yu, Suping Chen, Yi Luo, Glenn D Prestwich, Marcella M Mascarenhas, Hari G Garg, Deborah A Quinn, Robert J Homer, Daniel R Goldstein, Richard Bucala, Patty J Lee, Ruslan Medzhitov, Paul W Noble
Affiliations
- PMID: 16244651
- DOI: 10.1038/nm1315
Comparative Study
Regulation of lung injury and repair by Toll-like receptors and hyaluronan
Dianhua Jiang et al. Nat Med. 2005 Nov.
Abstract
Mechanisms that regulate inflammation and repair after acute lung injury are incompletely understood. The extracellular matrix glycosaminoglycan hyaluronan is produced after tissue injury and impaired clearance results in unremitting inflammation. Here we report that hyaluronan degradation products require MyD88 and both Toll-like receptor (TLR)4 and TLR2 in vitro and in vivo to initiate inflammatory responses in acute lung injury. Hyaluronan fragments isolated from serum of individuals with acute lung injury stimulated macrophage chemokine production in a TLR4- and TLR2-dependent manner. Myd88(-/-) and Tlr4(-/-)Tlr2(-/-) mice showed impaired transepithelial migration of inflammatory cells but decreased survival and enhanced epithelial cell apoptosis after lung injury. Lung epithelial cell-specific overexpression of high-molecular-mass hyaluronan was protective against acute lung injury. Furthermore, epithelial cell-surface hyaluronan was protective against apoptosis, in part, through TLR-dependent basal activation of NF-kappaB. Hyaluronan-TLR2 and hyaluronan-TLR4 interactions provide signals that initiate inflammatory responses, maintain epithelial cell integrity and promote recovery from acute lung injury.
Comment in
- TLRs play good cop, bad cop in the lung.
O'Neill LA. O'Neill LA. Nat Med. 2005 Nov;11(11):1161-2. doi: 10.1038/nm1105-1161. Nat Med. 2005. PMID: 16270071 No abstract available.
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