The role of apoptosis in the development and function of T lymphocytes - PubMed (original) (raw)

Review

. 2005 Oct;15(10):749-69.

doi: 10.1038/sj.cr.7290345.

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• PMID: 16246265
• DOI: 10.1038/sj.cr.7290345

Review

The role of apoptosis in the development and function of T lymphocytes

Nu Zhang et al. Cell Res. 2005 Oct.

Abstract

Apoptosis plays an essential role in T cell biology. Thymocytes expressing nonfunctional or autoreactive TCRs are eliminated by apoptosis during development. Apoptosis also leads to the deletion of expanded effector T cells during immune responses. The dysregulation of apoptosis in the immune system results in autoimmunity, tumorogenesis and immunodeficiency. Two major pathways lead to apoptosis: the intrinsic cell death pathway controlled by Bcl-2 family members and the extrinsic cell death pathway controlled by death receptor signaling. These two pathways work together to regulate T lymphocyte development and function.

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