Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor - PubMed (original) (raw)

. 2006 Feb 15;107(4):1491-6.

doi: 10.1182/blood-2005-04-1684. Epub 2005 Oct 25.

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• PMID: 16249389
• DOI: 10.1182/blood-2005-04-1684

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Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor

Satoko Tahara-Hanaoka et al. Blood. 2006.

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Abstract

The poliovirus receptor CD155 and its family member CD112 (nectin-2) are the ligands for the activating cell-surface receptor DNAM-1 on CD8+ T cells and natural killer (NK) cells. Here, we demonstrate that, whereas the RMA tumor grew in syngeneic mice, DNAM-1 ligand-transduced RMA was rejected, in which CD8+ T cells and NK cells played an essential role. Importantly, CD8+ memory cytotoxic T cells to parental RMA were generated in these mice. We found that DNAM-1 was also expressed on CD8alpha+, rather than CD8alpha-, dendritic cells (DCs). Cross-linking DNAM-1 induced maturation of CD8alpha+ DCs. Antigen presentation by these stimulated DCs drove Th1 cells. Moreover, the rejection of DNAM-1 ligand-transduced RMA was canceled in CD4+ T-cell-depleted and major histocompatibility complex class II-deficient mice. Taken together, these results suggest that DNAM-1 ligands stimulate innate immunity by CD8alpha+ DCs as well as NK cells, which efficiently prime cell-mediated tumor-specific immunity.

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