The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles - PubMed (original) (raw)
. 2005 Oct 28;310(5748):674-6.
doi: 10.1126/science.1118476.
Affiliations
- PMID: 16254184
- DOI: 10.1126/science.1118476
The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles
Catherine A Mueller et al. Science. 2005.
Abstract
Many pathogenic bacteria use injectisomes to deliver effector proteins into host cells through type III secretion. Injectisomes consist of a basal body embedded in the bacterial membranes and a needle. In Yersinia, translocation of effectors requires the YopB and YopD proteins, which form a pore in the target cell membrane, and the LcrV protein, which assists the assembly of the pore. Here we report that LcrV forms a distinct structure at the tip of the needle, the tip complex. This unique localization of LcrV may explain its crucial role in the translocation process and its efficacy as the main protective antigen against plague.
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