Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study - PubMed (original) (raw)
Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study
Eha Nurk et al. Ann Neurol. 2005 Dec.
Abstract
We examined the relation between plasma total homocysteine (tHcy), folate, vitamin B12, and episodic memory in elderly community-dwelling subjects. A population-based study was conducted in 1992 and 1993, and subjects were re-investigated after 6 years. Plasma analytes were determined on both occasions. At follow-up, memory performance, using the Kendrick Object Learning Test, was investigated in 2,189 subjects (age, 65-67 years at baseline). Subjects with memory deficit (test score, < 25) had higher tHcy and lower folate at follow-up compared with those without memory deficit: 12.6 (95% confidence interval [CI], 12.1, 13.1) versus 11.5 (95% CI, 11.3, 11.6) micromol/L (p < 0.001) for tHcy, and 6.7 (95% CI, 6.2, 7.1) versus 7.6 (95% CI, 7.5, 7.8) nmol/L (p < 0.001) for folate. The risk of memory deficit increased according to quintiles of tHcy both at baseline and at follow-up. A decline in tHcy, or an increase in folate, over a 6-year period was associated with a higher memory test score; and vice versa. These findings indicate that increased plasma tHcy is an independent risk factor for memory deficit both cross-sectionally and prospectively, and that a "favorable" change in folate or tHcy concentrations over time is associated with better memory performance.
Similar articles
- Plasma homocysteine, folate, and vitamin B 12 and the risk of hip fracture: the hordaland homocysteine study.
Gjesdal CG, Vollset SE, Ueland PM, Refsum H, Meyer HE, Tell GS. Gjesdal CG, et al. J Bone Miner Res. 2007 May;22(5):747-56. doi: 10.1359/jbmr.070210. J Bone Miner Res. 2007. PMID: 17295607 Clinical Trial. - Total serum homocysteine, folate and vitamin B12 in a Greek school age population.
Papandreou D, Mavromichalis I, Makedou A, Rousso I, Arvanitidou M. Papandreou D, et al. Clin Nutr. 2006 Oct;25(5):797-802. doi: 10.1016/j.clnu.2006.02.006. Epub 2006 May 11. Clin Nutr. 2006. PMID: 16690175 - Folate and cobalamin synergistically decrease the risk of high plasma homocysteine in a nonsupplemented elderly institutionalized population.
Huerta JM, González S, Vigil E, Prada M, San Martín J, Fernández S, Patterson AM, Lasheras C. Huerta JM, et al. Clin Biochem. 2004 Oct;37(10):904-10. doi: 10.1016/j.clinbiochem.2004.06.012. Clin Biochem. 2004. PMID: 15369722 - Homocysteine increases the risk of mortality in elderly individuals.
González S, Huerta JM, Fernández S, Patterson AM, Lasheras C. González S, et al. Br J Nutr. 2007 Jun;97(6):1138-43. doi: 10.1017/S0007114507691958. Epub 2007 Mar 19. Br J Nutr. 2007. PMID: 17367569 - The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease.
Refsum H, Nurk E, Smith AD, Ueland PM, Gjesdal CG, Bjelland I, Tverdal A, Tell GS, Nygård O, Vollset SE. Refsum H, et al. J Nutr. 2006 Jun;136(6 Suppl):1731S-1740S. doi: 10.1093/jn/136.6.1731S. J Nutr. 2006. PMID: 16702348 Review.
Cited by
- Folate - a scoping review for Nordic Nutrition Recommendations 2023.
Bjørke-Monsen AL, Ueland PM. Bjørke-Monsen AL, et al. Food Nutr Res. 2023 Dec 26;67. doi: 10.29219/fnr.v67.10258. eCollection 2023. Food Nutr Res. 2023. PMID: 38187793 Free PMC article. Review. - Homocysteine, Cognitive Functions, and Degenerative Dementias: State of the Art.
Luzzi S, Cherubini V, Falsetti L, Viticchi G, Silvestrini M, Toraldo A. Luzzi S, et al. Biomedicines. 2022 Oct 28;10(11):2741. doi: 10.3390/biomedicines10112741. Biomedicines. 2022. PMID: 36359260 Free PMC article. Review. - Hyperhomocysteinemia: Metabolic Role and Animal Studies with a Focus on Cognitive Performance and Decline-A Review.
Nieraad H, Pannwitz N, Bruin N, Geisslinger G, Till U. Nieraad H, et al. Biomolecules. 2021 Oct 19;11(10):1546. doi: 10.3390/biom11101546. Biomolecules. 2021. PMID: 34680179 Free PMC article. Review. - Homocysteine and Folic Acid: Risk Factors for Alzheimer's Disease-An Updated Meta-Analysis.
Wang Q, Zhao J, Chang H, Liu X, Zhu R. Wang Q, et al. Front Aging Neurosci. 2021 May 26;13:665114. doi: 10.3389/fnagi.2021.665114. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34122042 Free PMC article. - The Association Between Folate and Alzheimer's Disease: A Systematic Review and Meta-Analysis.
Zhang X, Bao G, Liu D, Yang Y, Li X, Cai G, Liu Y, Wu Y. Zhang X, et al. Front Neurosci. 2021 Apr 14;15:661198. doi: 10.3389/fnins.2021.661198. eCollection 2021. Front Neurosci. 2021. PMID: 33935641 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical