Widespread neuronal degeneration after ibotenic acid lesioning of cholinergic neurons in the nucleus basalis revealed by in situ hybridization - PubMed (original) (raw)
Widespread neuronal degeneration after ibotenic acid lesioning of cholinergic neurons in the nucleus basalis revealed by in situ hybridization
N Lindefors et al. Neurosci Lett. 1992.
Abstract
In efforts to test the cholinergic hypothesis for Alzheimer's disease and to create an animal model for this disease, ibotenic acid has been used to lesion cholinergic neurons in the basal forebrain. In this study we have used in situ hybridization with oligonucleotide probes specific for mRNAs encoding choline acetyltransferase and glutamic acid decarboxylase, respectively, to study the effects of such a lesion. Our results show that lesion paradigms normally used to induce neuronal degeneration in nucleus basalis by ibotenic acid not only lesion the cholinergic neurons within this nucleus, but in addition, a major fraction of gamma-aminobutyric acid (GABA) neurons in nucleus basalis, substantia innominata, globus pallidus and ventral pallidum.
Similar articles
- Comparison of intracranial infusions of colchicine and ibotenic acid as models of neurodegeneration in the basal forebrain.
Shaughnessy LW, Barone S Jr, Mundy WR, Herr DW, Tilson HA. Shaughnessy LW, et al. Brain Res. 1994 Feb 21;637(1-2):15-26. doi: 10.1016/0006-8993(94)91212-2. Brain Res. 1994. PMID: 8180792 - Muscle-derived trophic factors influencing cholinergic neurons in vitro and in vivo.
Appel SH, McManaman JL, Oppenheim R, Haverkamp L, Vaca K. Appel SH, et al. Prog Brain Res. 1989;79:251-6. doi: 10.1016/s0079-6123(08)62484-x. Prog Brain Res. 1989. PMID: 2685898 Review. No abstract available. - Chemical signalling and striatal interneurones.
Emson PC, Augood SJ, Señaris R, Guerara Guzman R, Kishimoto J, Kadowaki K, Norris PJ, Kendrick KM. Emson PC, et al. Prog Brain Res. 1993;99:155-65. doi: 10.1016/s0079-6123(08)61344-8. Prog Brain Res. 1993. PMID: 8108546 Review. No abstract available.
Cited by
- Changes in electrocortical power and coherence in response to the selective cholinergic immunotoxin 192 IgG-saporin.
Holschneider DP, Waite JJ, Leuchter AF, Walton NY, Scremin OU. Holschneider DP, et al. Exp Brain Res. 1999 May;126(2):270-80. doi: 10.1007/s002210050736. Exp Brain Res. 1999. PMID: 10369149 Free PMC article. - Lesions of the nucleus basalis magnocellularis induced by 192 IgG-saporin block memory enhancement with posttraining norepinephrine in the basolateral amygdala.
Power AE, Thal LJ, McGaugh JL. Power AE, et al. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2315-9. doi: 10.1073/pnas.022627799. Epub 2002 Feb 5. Proc Natl Acad Sci U S A. 2002. PMID: 11830635 Free PMC article.