Association of cardiovascular risk factors with pattern of lower limb atherosclerosis in 2659 patients undergoing angioplasty - PubMed (original) (raw)
Comparative Study
doi: 10.1016/j.ejvs.2005.09.006. Epub 2005 Nov 2.
Affiliations
- PMID: 16269257
- DOI: 10.1016/j.ejvs.2005.09.006
Free article
Comparative Study
Association of cardiovascular risk factors with pattern of lower limb atherosclerosis in 2659 patients undergoing angioplasty
N Diehm et al. Eur J Vasc Endovasc Surg. 2006 Jan.
Free article
Abstract
Objectives: Aim of this study is to correlate distribution pattern of lower limb atherosclerosis with cardiovascular risk factor profile of patients with peripheral arterial occlusive disease (PAD).
Patients and methods: Analysis is based on a consecutive series of 2659 patients (1583 men, 1076 women, 70+/-11 years) with chronic PAD of atherosclerotic origin undergoing primary endovascular treatment of lower extremity arteries. Pattern of atherosclerosis was grouped into iliac (n=1166), femoropopliteal (n=2151) and infrageniculate (n=888) disease defined according to target lesions treated. A multivariable multinomial logistic regression analysis was performed to assess relation with age, gender and classical cardiovascular risk factors (diabetes mellitus, arterial hypertension, hypercholesterolemia, cigarette smoking) using femoropopliteal disease as reference.
Results: Iliac disease was associated with younger age (RRR 0.95 per year of age, 95%-CI 0.94-0.96, p<0.001), male gender (RRR 1.32, 95%-CI 1.09-1.59, p=0.004) and cigarette smoking (RRR 2.02, 95%-CI 1.68-2.42, p<0.001). Infrageniculate disease was associated with higher age (RRR 1.02, 95%-CI 1.01-1.02, p<0.001), male gender (RRR 1.23, 95%-CI 1.06-1.41, p=0.005) and diabetes mellitus (RRR 1.68, 95%-CI 1.47-1.92, p<0.001). Hypercholesterolemia was less prevalent in patients with lesions below the knee (RRR 0.82, 95%-CI 0.71-0.94, p=0.006), whereas no distinct pattern was apparent related to arterial hypertension.
Conclusion: Clinical phenotype of peripheral atherosclerosis varies with prevalence of cardiovascular risk factors suggesting differences in mechanisms involved in iliac as compared with infrageniculate lesions. Identification of molecular mechanism might have influence on future therapeutic strategies in PAD patients.
Similar articles
- Prevalence of risk factors in patients with peripheral arterial disease. A clinical and epidemiological evaluation.
Novo S, Avellone G, Di Garbo V, Abrignani MG, Liquori M, Panno AV, Strano A. Novo S, et al. Int Angiol. 1992 Jul-Sep;11(3):218-29. Int Angiol. 1992. PMID: 1460357 - Optimal risk factor modification and medical management of the patient with peripheral arterial disease.
Chi YW, Jaff MR. Chi YW, et al. Catheter Cardiovasc Interv. 2008 Mar 1;71(4):475-89. doi: 10.1002/ccd.21401. Catheter Cardiovasc Interv. 2008. PMID: 18307227 Review. - Autoantibodies to the atheroma component beta2-glycoprotein I and risk of symptomatic peripheral artery disease.
Franck M, Staub HL, Petracco JB, Norman GL, Lassen AJ, Schiavo N, Borges RB, von Mühlen CA. Franck M, et al. Angiology. 2007 Jun-Jul;58(3):295-302. doi: 10.1177/0003319707302493. Angiology. 2007. PMID: 17626983 - Cardiovascular risk factors and venous thromboembolism: a meta-analysis.
Ageno W, Becattini C, Brighton T, Selby R, Kamphuisen PW. Ageno W, et al. Circulation. 2008 Jan 1;117(1):93-102. doi: 10.1161/CIRCULATIONAHA.107.709204. Epub 2007 Dec 17. Circulation. 2008. PMID: 18086925 - Cardiovascular risk factors in perspective.
Carruthers SG. Carruthers SG. Can Fam Physician. 1993 Feb;39:309-14. Can Fam Physician. 1993. PMID: 8495121 Free PMC article. Review.
Cited by
- Benefit and risk from paclitaxel-coated balloon angioplasty for the treatment of femoropopliteal artery disease: A systematic review and meta-analysis of randomised controlled trials.
Klumb C, Lehmann T, Aschenbach R, Eckardt N, Teichgräber U. Klumb C, et al. EClinicalMedicine. 2019 Oct 17;16:42-50. doi: 10.1016/j.eclinm.2019.09.004. eCollection 2019 Nov. EClinicalMedicine. 2019. PMID: 31832619 Free PMC article. - The relation of anatomical distribution of symptomatic peripheral arterial disease (PAD) with HbA1c level in patients with type 2 diabetes mellitus.
Shatnawi NJ, Al-Zoubi NA, Hawamdeh HM, Khader YS, Heis M, Al Omari M, Bataineh B. Shatnawi NJ, et al. Ther Adv Endocrinol Metab. 2021 Mar 9;12:20420188211000504. doi: 10.1177/20420188211000504. eCollection 2021. Ther Adv Endocrinol Metab. 2021. PMID: 33767809 Free PMC article. - Influence of atherosclerosis risk factors on the anatomical distribution of peripheral arterial disease in patients with chronic limb-threatening ischemia: a cross-sectional study.
Dos Santos VP, Cerutti CI, Alencar MJC, Queiroz AB, Ferreira LM, Fidelis C, de Araújo JS, Alves CAS. Dos Santos VP, et al. J Vasc Bras. 2023 Jul 17;22:e20230014. doi: 10.1590/1677-5449.202300141. eCollection 2023. J Vasc Bras. 2023. PMID: 37576729 Free PMC article. - Prevalence of extracranial carotid artery disease in symptomatic peripheral artery disease and implications for long-term outcome.
Zierfuss B, Witt-Dörring L, Ceschi A Santa Croce A, Hannes A, Staudacher M, Pesau G, Schlager O, Gschwandtner M, Schernthaner GH, Höbaus C. Zierfuss B, et al. Ann Med. 2025 Dec;57(1):2478313. doi: 10.1080/07853890.2025.2478313. Epub 2025 Mar 13. Ann Med. 2025. PMID: 40079756 Free PMC article. - Study protocol for a multicentre comparative diagnostic accuracy study of tools to establish the presence and severity of peripheral arterial disease in people with diabetes mellitus: the DM PAD study.
Normahani P, Burgess L, Norrie J, Epstein DM, Kandiyil N, Saratzis A, Smith S, Khunti K, Edmonds M, Ahluwalia R, Coward T, Hartshorne T, Ashwell S, Shalhoub J, Pigott E, Davies AH, Jaffer U; DM PAD study investigators. Normahani P, et al. BMJ Open. 2022 Nov 3;12(11):e066950. doi: 10.1136/bmjopen-2022-066950. BMJ Open. 2022. PMID: 36328388 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical