Association of cardiovascular risk factors with pattern of lower limb atherosclerosis in 2659 patients undergoing angioplasty - PubMed (original) (raw)
Comparative Study
doi: 10.1016/j.ejvs.2005.09.006. Epub 2005 Nov 2.
Affiliations
- PMID: 16269257
- DOI: 10.1016/j.ejvs.2005.09.006
Free article
Comparative Study
Association of cardiovascular risk factors with pattern of lower limb atherosclerosis in 2659 patients undergoing angioplasty
N Diehm et al. Eur J Vasc Endovasc Surg. 2006 Jan.
Free article
Abstract
Objectives: Aim of this study is to correlate distribution pattern of lower limb atherosclerosis with cardiovascular risk factor profile of patients with peripheral arterial occlusive disease (PAD).
Patients and methods: Analysis is based on a consecutive series of 2659 patients (1583 men, 1076 women, 70+/-11 years) with chronic PAD of atherosclerotic origin undergoing primary endovascular treatment of lower extremity arteries. Pattern of atherosclerosis was grouped into iliac (n=1166), femoropopliteal (n=2151) and infrageniculate (n=888) disease defined according to target lesions treated. A multivariable multinomial logistic regression analysis was performed to assess relation with age, gender and classical cardiovascular risk factors (diabetes mellitus, arterial hypertension, hypercholesterolemia, cigarette smoking) using femoropopliteal disease as reference.
Results: Iliac disease was associated with younger age (RRR 0.95 per year of age, 95%-CI 0.94-0.96, p<0.001), male gender (RRR 1.32, 95%-CI 1.09-1.59, p=0.004) and cigarette smoking (RRR 2.02, 95%-CI 1.68-2.42, p<0.001). Infrageniculate disease was associated with higher age (RRR 1.02, 95%-CI 1.01-1.02, p<0.001), male gender (RRR 1.23, 95%-CI 1.06-1.41, p=0.005) and diabetes mellitus (RRR 1.68, 95%-CI 1.47-1.92, p<0.001). Hypercholesterolemia was less prevalent in patients with lesions below the knee (RRR 0.82, 95%-CI 0.71-0.94, p=0.006), whereas no distinct pattern was apparent related to arterial hypertension.
Conclusion: Clinical phenotype of peripheral atherosclerosis varies with prevalence of cardiovascular risk factors suggesting differences in mechanisms involved in iliac as compared with infrageniculate lesions. Identification of molecular mechanism might have influence on future therapeutic strategies in PAD patients.
Similar articles
- Prevalence of risk factors in patients with peripheral arterial disease. A clinical and epidemiological evaluation.
Novo S, Avellone G, Di Garbo V, Abrignani MG, Liquori M, Panno AV, Strano A. Novo S, et al. Int Angiol. 1992 Jul-Sep;11(3):218-29. Int Angiol. 1992. PMID: 1460357 - Optimal risk factor modification and medical management of the patient with peripheral arterial disease.
Chi YW, Jaff MR. Chi YW, et al. Catheter Cardiovasc Interv. 2008 Mar 1;71(4):475-89. doi: 10.1002/ccd.21401. Catheter Cardiovasc Interv. 2008. PMID: 18307227 Review. - Autoantibodies to the atheroma component beta2-glycoprotein I and risk of symptomatic peripheral artery disease.
Franck M, Staub HL, Petracco JB, Norman GL, Lassen AJ, Schiavo N, Borges RB, von Mühlen CA. Franck M, et al. Angiology. 2007 Jun-Jul;58(3):295-302. doi: 10.1177/0003319707302493. Angiology. 2007. PMID: 17626983 - Cardiovascular risk factors and venous thromboembolism: a meta-analysis.
Ageno W, Becattini C, Brighton T, Selby R, Kamphuisen PW. Ageno W, et al. Circulation. 2008 Jan 1;117(1):93-102. doi: 10.1161/CIRCULATIONAHA.107.709204. Epub 2007 Dec 17. Circulation. 2008. PMID: 18086925 - Cardiovascular risk factors in perspective.
Carruthers SG. Carruthers SG. Can Fam Physician. 1993 Feb;39:309-14. Can Fam Physician. 1993. PMID: 8495121 Free PMC article. Review.
Cited by
- New semiquantitative ultrasonographic score for peripheral arterial disease assessment and its association with cardiovascular risk factors.
Santoro L, Ferraro PM, Flex A, Nesci A, De Matteis G, Di Giorgio A, Zaccone V, Gambaro G, Gasbarrini A, Santoliquido A. Santoro L, et al. Hypertens Res. 2016 Dec;39(12):868-873. doi: 10.1038/hr.2016.88. Epub 2016 Jul 14. Hypertens Res. 2016. PMID: 27412797 Free PMC article. - [Reconstruction of lower limbs in old age-an interdisciplinary approach : Strategies for trauma surgery, vascular surgery and plastic surgery].
Reiter G, Thomas B, Kühner C, Hundeshagen G, Weil F, Wittenberg G, Kloos S, Grützner PA, Kneser U. Reiter G, et al. Chirurg. 2019 Oct;90(10):806-815. doi: 10.1007/s00104-019-01023-7. Chirurg. 2019. PMID: 31501936 Review. German. - Critical limb ischemia: current challenges and future prospects.
Uccioli L, Meloni M, Izzo V, Giurato L, Merolla S, Gandini R. Uccioli L, et al. Vasc Health Risk Manag. 2018 Apr 26;14:63-74. doi: 10.2147/VHRM.S125065. eCollection 2018. Vasc Health Risk Manag. 2018. PMID: 29731636 Free PMC article. Review. - Patency of the arterial pedal-plantar arch in patients with chronic kidney disease or diabetes mellitus.
Haine A, Haynes AG, Limacher A, Sebastian T, Saengprakai W, Fuss T, Baumgartner I. Haine A, et al. Ther Adv Cardiovasc Dis. 2018 May;12(5):145-153. doi: 10.1177/1753944718756605. Epub 2018 Feb 12. Ther Adv Cardiovasc Dis. 2018. PMID: 29431578 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical