Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth - PubMed (original) (raw)

. 2005 Nov 4;310(5749):858-63.

doi: 10.1126/science.1117541.

Affiliations

• PMID: 16272123
• DOI: 10.1126/science.1117541

Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth

Motojiro Yoshihara et al. Science. 2005.

Abstract

The molecular pathways involved in retrograde signal transduction at synapses and the function of retrograde communication are poorly understood. Here, we demonstrate that postsynaptic calcium 2+ ion (Ca2+) influx through glutamate receptors and subsequent postsynaptic vesicle fusion trigger a robust induction of presynaptic miniature release after high-frequency stimulation at Drosophila neuromuscular junctions. An isoform of the synaptotagmin family, synaptotagmin 4 (Syt 4), serves as a postsynaptic Ca2+ sensor to release retrograde signals that stimulate enhanced presynaptic function through activation of the cyclic adenosine monophosphate (cAMP)-cAMP-dependent protein kinase pathway. Postsynaptic Ca2+ influx also stimulates local synaptic differentiation and growth through Syt 4-mediated retrograde signals in a synapse-specific manner.

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