Mdv1 interacts with assembled dnm1 to promote mitochondrial division - PubMed (original) (raw)

. 2006 Jan 27;281(4):2177-83.

doi: 10.1074/jbc.M507943200. Epub 2005 Nov 4.

Affiliations

• PMID: 16272155
• DOI: 10.1074/jbc.M507943200

Free article

Mdv1 interacts with assembled dnm1 to promote mitochondrial division

Kari Naylor et al. J Biol Chem. 2006.

Free article

Abstract

The dynamin-related GTPase, Dnm1, self-assembles into punctate structures that are targeted to the outer mitochondrial membrane where they mediate mitochondrial division. Post-targeting, Dnm1-dependent division is controlled by the actions of the WD repeat protein, Mdv1, and the mitochondrial tetratricopeptide repeat-like outer membrane protein, Fis1. Our previous studies suggest a model where at this step Mdv1 functions as an adaptor linking Fis1 with Dnm1. To gain insight into the exact role of the Fis1.Mdv1.Dnm1 complex in mitochondrial division, we performed a structure-function analysis of the Mdv1 adaptor. Our analysis suggests that dynamic interactions between Mdv1 and Dnm1 play a key role in division by regulating Dnm1 self-assembly.

PubMed Disclaimer

Similar articles

• Dimeric Dnm1-G385D interacts with Mdv1 on mitochondria and can be stimulated to assemble into fission complexes containing Mdv1 and Fis1.
  Bhar D, Karren MA, Babst M, Shaw JM. Bhar D, et al. J Biol Chem. 2006 Jun 23;281(25):17312-17320. doi: 10.1074/jbc.M513530200. Epub 2006 Apr 6. J Biol Chem. 2006. PMID: 16601120
• Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal arm.
  Wells RC, Picton LK, Williams SCP, Tan FJ, Hill RB. Wells RC, et al. J Biol Chem. 2007 Nov 16;282(46):33769-33775. doi: 10.1074/jbc.M700807200. Epub 2007 Sep 20. J Biol Chem. 2007. PMID: 17884824 Free PMC article.
• Crystal structure of mitochondrial fission complex reveals scaffolding function for mitochondrial division 1 (Mdv1) coiled coil.
  Zhang Y, Chan NC, Ngo HB, Gristick H, Chan DC. Zhang Y, et al. J Biol Chem. 2012 Mar 23;287(13):9855-9861. doi: 10.1074/jbc.M111.329359. Epub 2012 Feb 1. J Biol Chem. 2012. PMID: 22303011 Free PMC article.
• Molecular Basis of Mitochondrial and Peroxisomal Division Machineries.
  Imoto Y, Itoh K, Fujiki Y. Imoto Y, et al. Int J Mol Sci. 2020 Jul 30;21(15):5452. doi: 10.3390/ijms21155452. Int J Mol Sci. 2020. PMID: 32751702 Free PMC article. Review.
• The machines that divide and fuse mitochondria.
  Hoppins S, Lackner L, Nunnari J. Hoppins S, et al. Annu Rev Biochem. 2007;76:751-80. doi: 10.1146/annurev.biochem.76.071905.090048. Annu Rev Biochem. 2007. PMID: 17362197 Review.

Cited by

• Chemical inhibition of phosphatidylcholine biogenesis reveals its role in mitochondrial division.
  Shiino H, Tashiro S, Hashimoto M, Sakata Y, Hosoya T, Endo T, Kojima H, Tamura Y. Shiino H, et al. iScience. 2024 Feb 10;27(3):109189. doi: 10.1016/j.isci.2024.109189. eCollection 2024 Mar 15. iScience. 2024. PMID: 38420588 Free PMC article.
• A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope.
  Mannino PJ, Perun A, Surovstev I, Ader NR, Shao L, Melia TJ, King MC, Lusk CP. Mannino PJ, et al. bioRxiv [Preprint]. 2024 Feb 15:2024.02.14.580336. doi: 10.1101/2024.02.14.580336. bioRxiv. 2024. PMID: 38405892 Free PMC article. Preprint.
• Inhibition of Drp1 orchestrates the responsiveness of breast cancer cells to paclitaxel but insignificantly relieves paclitaxel-related ovarian damage in mice.
  Alalawy AI, Sakran M, Alzuaibr FM, Alotaibi MA, El-Hefnawy ME, Hazazi AY, El-Gendy SM, Aidy EA, Effat H, Ismail DF, Hessien M. Alalawy AI, et al. Sci Rep. 2023 Dec 20;13(1):22782. doi: 10.1038/s41598-023-49578-0. Sci Rep. 2023. PMID: 38129495 Free PMC article.
• Biased placement of Mitochondria fission facilitates asymmetric inheritance of protein aggregates during yeast cell division.
  Sun G, Hwang C, Jung T, Liu J, Li R. Sun G, et al. PLoS Comput Biol. 2023 Nov 27;19(11):e1011588. doi: 10.1371/journal.pcbi.1011588. eCollection 2023 Nov. PLoS Comput Biol. 2023. PMID: 38011208 Free PMC article.
• The AAA-ATPase Yta4/ATAD1 interacts with the mitochondrial divisome to inhibit mitochondrial fission.
  He J, Liu K, Wu Y, Zhao C, Yan S, Chen JH, Hu L, Wang D, Zheng F, Wei W, Xu C, Huang C, Liu X, Yao X, Ding L, Fang Z, Tang AH, Fu C. He J, et al. PLoS Biol. 2023 Aug 17;21(8):e3002247. doi: 10.1371/journal.pbio.3002247. eCollection 2023 Aug. PLoS Biol. 2023. PMID: 37590302 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • H1 Connect

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • Saccharomyces Genome Database