RNA reigns in neurons - PubMed (original) (raw)

Comparative Study

RNA reigns in neurons

Henri Tiedge. Neuron. 2005.

Abstract

A workshop entitled "RNA Control of Neuronal Function" was recently held in Kfar Blum, Israel. The main topics discussed at the meeting included neuronal RNA targeting mechanisms and the contributing codes and components, translational control mechanisms in dendrites and axons, and the relevance of these mechanisms for neuronal development, plasticity, and dysfunction.

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Figure 1

Figure 1

Repressors-R-Us: Translational Control at the Synapse Multiple repression mechanisms are in operation in postsynaptic microdomains. Diverse repressors–which may be RNAs or proteins–may target specific mRNAs, initiation factors, and initiation or elongation complexes. For any given mRNA, all relevant repressors have to be removed or inactivated before the cognate protein can be synthesized following trans-synaptic stimulation. The relative concentrations of ribosomes, mRNAs, initiation factors, elongation factors, etc., at the synapse are unknown. Illustration provided by H. Wang.

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