Elevated peptide YY levels in adolescent girls with anorexia nervosa - PubMed (original) (raw)
Comparative Study
. 2006 Mar;91(3):1027-33.
doi: 10.1210/jc.2005-1878. Epub 2005 Nov 8.
Affiliations
- PMID: 16278259
- DOI: 10.1210/jc.2005-1878
Comparative Study
Elevated peptide YY levels in adolescent girls with anorexia nervosa
Madhusmita Misra et al. J Clin Endocrinol Metab. 2006 Mar.
Abstract
Background: Peptide YY (PYY) is an intestinally derived anorexigen that acts via the Y2 receptor, and Y2 receptor deletion in rodents increases bone formation. Anorexia nervosa (AN) is associated with a deliberate reduction in food intake and low bone density, but endocrine modulators of food intake in AN are not known. In addition, known regulators of bone turnover, such as GH, cortisol, and estrogen, explain only a fraction of the variability in bone turnover marker levels.
Hypotheses: We hypothesized that PYY may be elevated in AN compared with controls and may contribute to decreased food intake and bone formation.
Methods: Fasting PYY was examined in 23 AN girls and 21 healthy adolescents 12-18 yr old. We also examined GH, cortisol, ghrelin, and leptin (overnight frequent sampling) and fasting IGF-I, estradiol, total T3, and bone markers. Macronutrient intake and resting energy expenditure (REE) were measured.
Results: AN girls had higher PYY levels compared with controls (17.8 +/- 10.2 vs. 4.8 +/- 4.3 pg/ml; P < 0.0001). Predictors of log PYY were nutritional markers, including body mass index (r = -0.62; P < 0.0001), fat mass (r = -0.55; P = 0.0003), and REE (r = -0.51; P = 0.0006), and hormones, including GH (r = 0.38; P = 0.004) and T3 (r = -0.59; P = 0.0001). Body mass index, fat mass, REE, GH, and T3 explained 68% of the variability of log PYY. Log PYY predicted percentage of calories from fat (r = -0.56; P = 0.0002) and independently predicted osteocalcin (r = -0.45; P = 0.003), bone-specific alkaline phosphatase (r = -0.46; P = 0.003), N-telopeptide/creatinine (r = -0.55; P = 0.0003), and deoxypyridinoline/creatinine (r = -0.52; P = 0.001) on regression modeling.
Conclusion: Elevated PYY may contribute to reduced intake and decreased bone turnover in AN.
Comment in
- Editorial: from gut to mind--hormonal satiety signals and anorexia nervosa.
Chaudhri OB, Field BC, Bloom SR. Chaudhri OB, et al. J Clin Endocrinol Metab. 2006 Mar;91(3):797-8. doi: 10.1210/jc.2005-2729. J Clin Endocrinol Metab. 2006. PMID: 16522706 No abstract available.
Similar articles
- Relationships between serum adipokines, insulin levels, and bone density in girls with anorexia nervosa.
Misra M, Miller KK, Cord J, Prabhakaran R, Herzog DB, Goldstein M, Katzman DK, Klibanski A. Misra M, et al. J Clin Endocrinol Metab. 2007 Jun;92(6):2046-52. doi: 10.1210/jc.2006-2855. Epub 2007 Mar 13. J Clin Endocrinol Metab. 2007. PMID: 17356044 - Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents.
Misra M, Miller KK, Kuo K, Griffin K, Stewart V, Hunter E, Herzog DB, Klibanski A. Misra M, et al. Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E347-56. doi: 10.1152/ajpendo.00615.2004. Epub 2005 Mar 8. Am J Physiol Endocrinol Metab. 2005. PMID: 15755766 Clinical Trial. - Ghrelin and bone metabolism in adolescent girls with anorexia nervosa and healthy adolescents.
Misra M, Miller KK, Stewart V, Hunter E, Kuo K, Herzog DB, Klibanski A. Misra M, et al. J Clin Endocrinol Metab. 2005 Sep;90(9):5082-7. doi: 10.1210/jc.2005-0512. Epub 2005 Jul 5. J Clin Endocrinol Metab. 2005. PMID: 15998770 - Menstrual irregularities and energy deficiency in physically active women: the role of ghrelin, PYY and adipocytokines.
Scheid JL, De Souza MJ. Scheid JL, et al. Med Sport Sci. 2010;55:82-102. doi: 10.1159/000321974. Epub 2010 Oct 14. Med Sport Sci. 2010. PMID: 20956862 Review. - Neuroendocrine consequences of anorexia nervosa in adolescents.
Misra M, Klibanski A. Misra M, et al. Endocr Dev. 2010;17:197-214. doi: 10.1159/000262540. Epub 2009 Nov 24. Endocr Dev. 2010. PMID: 19955768 Free PMC article. Review.
Cited by
- Effects of hypogonadism on bone metabolism in female adolescents and young adults.
Misra M. Misra M. Nat Rev Endocrinol. 2012 Jan 24;8(7):395-404. doi: 10.1038/nrendo.2011.238. Nat Rev Endocrinol. 2012. PMID: 22271187 Review. - Changes in Bone Mineral Density in Patients with Type 2 Diabetes After Different Bariatric Surgery Procedures and the Role of Gastrointestinal Hormones.
Guerrero-Pérez F, Casajoana A, Gómez-Vaquero C, Virgili N, López-Urdiales R, Hernández-Montoliu L, Pujol-Gebelli J, Osorio J, Alves C, Perez-Maraver M, Pellitero S, Vidal-Alabró A, Fernández-Veledo S, Vendrell J, Vilarrasa N. Guerrero-Pérez F, et al. Obes Surg. 2020 Jan;30(1):180-188. doi: 10.1007/s11695-019-04127-5. Obes Surg. 2020. PMID: 31420830 Clinical Trial. - Influence of ghrelin and adipocytokines on bone mineral density in adolescent female athletes with amenorrhea and eumenorrheic athletes.
Russell M, Misra M. Russell M, et al. Med Sport Sci. 2010;55:103-113. doi: 10.1159/000321975. Epub 2010 Oct 14. Med Sport Sci. 2010. PMID: 20956863 Free PMC article. Review. - Weight gain and restoration of menses as predictors of bone mineral density change in adolescent girls with anorexia nervosa-1.
Misra M, Prabhakaran R, Miller KK, Goldstein MA, Mickley D, Clauss L, Lockhart P, Cord J, Herzog DB, Katzman DK, Klibanski A. Misra M, et al. J Clin Endocrinol Metab. 2008 Apr;93(4):1231-7. doi: 10.1210/jc.2007-1434. Epub 2007 Dec 18. J Clin Endocrinol Metab. 2008. PMID: 18089702 Free PMC article. - Neuroendocrine adaptations to starvation.
Amorim T, Khiyami A, Latif T, Fazeli PK. Amorim T, et al. Psychoneuroendocrinology. 2023 Nov;157:106365. doi: 10.1016/j.psyneuen.2023.106365. Epub 2023 Aug 10. Psychoneuroendocrinology. 2023. PMID: 37573628 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources