Retroviral insertional mutagenesis: past, present and future - PubMed (original) (raw)
Review
. 2005 Nov 21;24(52):7656-72.
doi: 10.1038/sj.onc.1209043.
Affiliations
- PMID: 16299527
- DOI: 10.1038/sj.onc.1209043
Review
Retroviral insertional mutagenesis: past, present and future
A G Uren et al. Oncogene. 2005.
Abstract
Retroviral insertion mutagenesis screens in mice are powerful tools for efficient identification of oncogenic mutations in an in vivo setting. Many oncogenes identified in these screens have also been shown to play a causal role in the development of human cancers. Sequencing and annotation of the mouse genome, along with recent improvements in insertion site cloning has greatly facilitated identification of oncogenic events in retrovirus-induced tumours. In this review, we discuss the features of retroviral insertion mutagenesis screens, covering the mechanisms by which retroviral insertions mutate cellular genes, the practical aspects of insertion site cloning, the identification and analysis of common insertion sites, and finally we address the potential for use of somatic insertional mutagens in the study of nonhaematopoietic and nonmammary tumour types.
Similar articles
- Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse.
Collier LS, Carlson CM, Ravimohan S, Dupuy AJ, Largaespada DA. Collier LS, et al. Nature. 2005 Jul 14;436(7048):272-6. doi: 10.1038/nature03681. Nature. 2005. PMID: 16015333 - Significance of murine retroviral mutagenesis for identification of disease genes in human acute myeloid leukemia.
Erkeland SJ, Verhaak RG, Valk PJ, Delwel R, Löwenberg B, Touw IP. Erkeland SJ, et al. Cancer Res. 2006 Jan 15;66(2):622-6. doi: 10.1158/0008-5472.CAN-05-2908. Cancer Res. 2006. PMID: 16423987 - Genetic screens in mammalian cells by enhanced retroviral mutagens.
Liu D, Yang X, Yang D, Songyang Z. Liu D, et al. Oncogene. 2000 Dec 7;19(52):5964-72. doi: 10.1038/sj.onc.1203992. Oncogene. 2000. PMID: 11146547 - Insertional mutagenesis in mice: new perspectives and tools.
Carlson CM, Largaespada DA. Carlson CM, et al. Nat Rev Genet. 2005 Jul;6(7):568-80. doi: 10.1038/nrg1638. Nat Rev Genet. 2005. PMID: 15995698 Review. - Cancer gene discovery: exploiting insertional mutagenesis.
Ranzani M, Annunziato S, Adams DJ, Montini E. Ranzani M, et al. Mol Cancer Res. 2013 Oct;11(10):1141-58. doi: 10.1158/1541-7786.MCR-13-0244. Epub 2013 Aug 8. Mol Cancer Res. 2013. PMID: 23928056 Free PMC article. Review.
Cited by
- Recombinant Adeno-Associated Virus Vectors for Gene Therapy of the Central Nervous System: Delivery Routes and Clinical Aspects.
Słyk Ż, Stachowiak N, Małecki M. Słyk Ż, et al. Biomedicines. 2024 Jul 9;12(7):1523. doi: 10.3390/biomedicines12071523. Biomedicines. 2024. PMID: 39062095 Free PMC article. Review. - The regulatory potential of transposable elements in maize.
Bubb KL, Hamm MO, Min JK, Ramirez-Corona B, Mueth NA, Ranchalis J, Vollger MR, Trapnell C, Cuperus JT, Queitsch C, Stergachis AB. Bubb KL, et al. bioRxiv [Preprint]. 2024 Jul 14:2024.07.10.602892. doi: 10.1101/2024.07.10.602892. bioRxiv. 2024. PMID: 39026747 Free PMC article. Preprint. - Optimal delivery of RNA interference by viral vectors for cancer therapy.
Wong B, Birtch R, Rezaei R, Jamieson T, Crupi MJF, Diallo JS, Ilkow CS. Wong B, et al. Mol Ther. 2023 Nov 1;31(11):3127-3145. doi: 10.1016/j.ymthe.2023.09.012. Epub 2023 Sep 20. Mol Ther. 2023. PMID: 37735876 Review. - Development of immortalized rhesus macaque kidney cells supporting infection with a panel of viruses.
Reiter S, Gärtner S, Decker K, Pöhlmann S, Winkler M. Reiter S, et al. PLoS One. 2023 May 5;18(5):e0284048. doi: 10.1371/journal.pone.0284048. eCollection 2023. PLoS One. 2023. PMID: 37146034 Free PMC article. - Still finding ways to augment the existing management of acute and chronic kidney diseases with targeted gene and cell therapies: Opportunities and hurdles.
Corridon PR. Corridon PR. Front Med (Lausanne). 2023 Mar 7;10:1143028. doi: 10.3389/fmed.2023.1143028. eCollection 2023. Front Med (Lausanne). 2023. PMID: 36960337 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous