Neoglycorandomization and chemoenzymatic glycorandomization: two complementary tools for natural product diversification - PubMed (original) (raw)

Review

. 2005 Nov;68(11):1696-711.

doi: 10.1021/np0502084.

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Review

Neoglycorandomization and chemoenzymatic glycorandomization: two complementary tools for natural product diversification

Joseph M Langenhan et al. J Nat Prod. 2005 Nov.

Abstract

In an effort to explore the contribution of the sugar constituents of pharmaceutically relevant glycosylated natural products, chemists have developed glycosylation methods that are amenable to the generation of libraries of analogues with a broad array of glycosidic attachments. Recently, two complementary glycorandomization strategies have been described, namely, neoglycorandomization, a chemical approach based on a one-step sugar ligation reaction that does not require any prior sugar protection or activation, and chemoenzymatic glycorandomization, a biocatalytic approach that relies on the substrate promiscuity of enzymes to activate and attach sugars to natural products. Since both methods require reducing sugars, this review first highlights recent advances in monosaccharide generation and then follows with an overview of recent progress in the development of neoglycorandomization and chemoenzymatic glycorandomization.

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