Risk of dementia in diabetes mellitus: a systematic review - PubMed (original) (raw)
Comparative Study
Risk of dementia in diabetes mellitus: a systematic review
Geert Jan Biessels et al. Lancet Neurol. 2006 Jan.
Erratum in
- Lancet Neurol. 2006 Feb;5(2):113
Abstract
The relation between diabetes and major types of dementia is controversial. This systematic review examines the incidence of dementia in people with diabetes mellitus. We identified 14 eligible longitudinal population-based studies of variable methodological quality. The incidence of "any dementia" was higher in individuals with diabetes than in those without diabetes in seven of ten studies reporting this aggregate outcome. This high risk included both Alzheimer's disease and vascular dementia (eight of 13 studies and six of nine studies respectively). Detailed data on modulating and mediating effects of glycaemic control, microvascular complications, and comorbidity (eg, hypertension and stroke) were generally absent. The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology, but which of these mechanisms are clinically relevant is unclear. Further high quality studies need to be initiated, with objective diabetes assessment, together with reliable methods to establish the contribution of vascular disease and other comorbidity to dementia.
Similar articles
- Nimodipine for primary degenerative, mixed and vascular dementia.
López-Arrieta, Birks J. López-Arrieta, et al. Cochrane Database Syst Rev. 2001;(1):CD000147. doi: 10.1002/14651858.CD000147. Cochrane Database Syst Rev. 2001. PMID: 11279679 Updated. - A rapid and systematic review of the clinical effectiveness and cost-effectiveness of topotecan for ovarian cancer.
Forbes C, Shirran L, Bagnall AM, Duffy S, ter Riet G. Forbes C, et al. Health Technol Assess. 2001;5(28):1-110. doi: 10.3310/hta5280. Health Technol Assess. 2001. PMID: 11701100 - Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia.
Mühlbauer V, Möhler R, Dichter MN, Zuidema SU, Köpke S, Luijendijk HJ. Mühlbauer V, et al. Cochrane Database Syst Rev. 2021 Dec 17;12(12):CD013304. doi: 10.1002/14651858.CD013304.pub2. Cochrane Database Syst Rev. 2021. PMID: 34918337 Free PMC article. - Systemic treatments for metastatic cutaneous melanoma.
Pasquali S, Hadjinicolaou AV, Chiarion Sileni V, Rossi CR, Mocellin S. Pasquali S, et al. Cochrane Database Syst Rev. 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2. Cochrane Database Syst Rev. 2018. PMID: 29405038 Free PMC article. - Comparison of cellulose, modified cellulose and synthetic membranes in the haemodialysis of patients with end-stage renal disease.
MacLeod A, Daly C, Khan I, Vale L, Campbell M, Wallace S, Cody J, Donaldson C, Grant A. MacLeod A, et al. Cochrane Database Syst Rev. 2001;(3):CD003234. doi: 10.1002/14651858.CD003234. Cochrane Database Syst Rev. 2001. PMID: 11687058 Updated.
Cited by
- Diabetes Impairs Wnt3 Protein-induced Neurogenesis in Olfactory Bulbs via Glutamate Transporter 1 Inhibition.
Wakabayashi T, Hidaka R, Fujimaki S, Asashima M, Kuwabara T. Wakabayashi T, et al. J Biol Chem. 2016 Jul 15;291(29):15196-211. doi: 10.1074/jbc.M115.672857. Epub 2016 May 20. J Biol Chem. 2016. PMID: 27226528 Free PMC article. - Insufficient Plasma Melatonin and Its Association With Neuropsychiatric Impairments in Patients With T2DM.
He S, Yu Y, Chen PQ, Sun HM, Gao XR, Sun HZ, Ge JF. He S, et al. J Diabetes Res. 2024 Jul 3;2024:5661751. doi: 10.1155/2024/5661751. eCollection 2024. J Diabetes Res. 2024. PMID: 38988702 Free PMC article. - Diabetes, hemoglobin A1c, and cognitive performance in older adults: is there any impact of frailty? Evidence from the ELSI-Brazil study.
Souza JG, Farias-Itao DS, Aliberti MJR, Alexandre TS, Szlejf C, Ferri CP, Lima-Costa MF, Suemoto CK. Souza JG, et al. Braz J Med Biol Res. 2024 Feb 19;57:e12939. doi: 10.1590/1414-431X2023e12939. eCollection 2024. Braz J Med Biol Res. 2024. PMID: 38381882 Free PMC article. - Association of regional white matter hyperintensity volumes with cognitive dysfunction and vascular risk factors in patients with amnestic mild cognitive impairment.
Hirao K, Yamashita F, Sakurai S, Tsugawa A, Haime R, Fukasawa R, Sato T, Kanetaka H, Umahara T, Sakurai H, Hanyu H, Shimizu S. Hirao K, et al. Geriatr Gerontol Int. 2021 Aug;21(8):644-650. doi: 10.1111/ggi.14211. Epub 2021 Jun 9. Geriatr Gerontol Int. 2021. PMID: 34105230 Free PMC article. - Impact of diabetes on cognitive function and brain structure.
Moheet A, Mangia S, Seaquist ER. Moheet A, et al. Ann N Y Acad Sci. 2015 Sep;1353:60-71. doi: 10.1111/nyas.12807. Epub 2015 Jul 1. Ann N Y Acad Sci. 2015. PMID: 26132277 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical