Interactions among the components of the interleukin-10 receptor complex - PubMed (original) (raw)
. 2006 Feb 10;340(2):377-85.
doi: 10.1016/j.bbrc.2005.11.182. Epub 2005 Dec 13.
Affiliations
- PMID: 16364239
- DOI: 10.1016/j.bbrc.2005.11.182
Interactions among the components of the interleukin-10 receptor complex
Christopher D Krause et al. Biochem Biophys Res Commun. 2006.
Abstract
We used fluorescence resonance energy transfer previously to show that the interferon-gamma (IFN-gamma) receptor complex is a preformed entity mediated by constitutive interactions between the IFN-gammaR2 and IFN-gammaR1 chains, and that this preassembled entity changes its structure after the treatment of cells with IFN-gamma. We applied this technique to determine the structure of the interleukin-10 (IL-10) receptor complex and whether it undergoes a similar conformational change after treatment of cells with IL-10. We report that, like the IFN-gamma receptor complex, the IL-10 receptor complex is preassembled: constitutive but weaker interactions occur between the IL-10R1 and IL-10R2 chains, and between two IL-10R2 chains. The IL-10 receptor complex undergoes no major conformational changes when cells are treated with cellular or Epstein-Barr viral IL-10. Receptor complex preassembly may be an inherent feature of Class 2 cytokine receptor complexes.
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