The glycosaminoglycans in human hepatic cancer - PubMed (original) (raw)
- PMID: 163683
The glycosaminoglycans in human hepatic cancer
J Kojima et al. Cancer Res. 1975 Mar.
Abstract
A method is proposed for the analysis of glycosaminoglycans that were isolated from human liver, combining cellulose acetate electrophoresis and enzymatic digestion with mucopolysaccharidases. The major constituent of glycossaminoglycans in the healthy liver is heparin sulfate and/or heparin (about 65%), with approximately equal quantities of dermatan sulfate and hyalauronic acid (about 13.5 and 13%, respectively) and a small amount of chondroitin sulfate. These components, especially chondroitin sulfate and hyaluronic acid, are markedly increased in hepatic carcinomas.